Impairments of Synaptic Plasticity in Aged Animals and in Animal Models of Alzheimer's Disease

被引：30
作者：
Balietti, Marta [2 ,3 ]
Tamagnini, Francesco [1 ]
Fattoretti, Patrizia [2 ,3 ]
Burattini, Costanza [1 ]
Casoli, Tiziana [2 ]
Platano, Daniela [4 ]
Lattanzio, Fabrizia [5 ]
Aicardi, Giorgio [1 ,6 ]
机构：
[1] Univ Bologna, Dept Human & Gen Physiol, I-40127 Bologna, Italy
[2] INRCA Sci Technol Area, Neurobiol Aging Lab, Ancona, Italy
[3] INRCA Sci Technol Area, Cellular Bioenerget Lab, Ancona, Italy
[4] Ist Ortoped Rizzoli, Lab Immunorheumatol & Tissue Regenerat, Bologna, Italy
[5] INRCA Sci Technol Area, Sci Direct, Ancona, Italy
[6] Univ Bologna, Interdept Ctr Luigi Galvani Study Biophys Bioinfo, I-40127 Bologna, Italy
来源：
REJUVENATION RESEARCH | 2012年 / 15卷 / 02期
关键词：
LONG-TERM POTENTIATION; THERAPEUTIC TARGET; KETOGENIC DIETS; AMYLOID-BETA; ADULT; BDNF; DEPRESSION; MORPHOLOGY; SECRETION; CORTEX;
D O I：
10.1089/rej.2012.1318
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging is associated with a gradual decline in cognitive functions, and more dramatic cognitive impairments occur in patients affected by Alzheimer's disease (AD). Electrophysiological and molecular studies performed in aged animals and in animal models of AD have shown that cognitive decline is associated with significant modifications in synaptic plasticity (i.e., activity-dependent changes in synaptic strength) and have elucidated some of the cellular mechanisms underlying this process. Morphological studies have revealed a correlation between the quality of memory performance and the extent of structural changes of synaptic contacts occurring during memory consolidation. We briefly review recent experimental evidence here.
引用
收藏
页码：235 / 238
页数：4
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