Monoterpene Glucosides from Ziziphora clinopodioides (Labiatae)

被引：6

作者：

Furukawa, Megumi ^{[1
]}

Oikawa, Naoki ^{[1
]}

Imohata, Toru ^{[2
]}

Makino, Mitsuko ^{[3
]}

Ogawa, Shoujiro ^{[2
]}

Iida, Takashi ^{[2
]}

Fujimoto, Yasuo ^{[3
]}

Kitanaka, Susumu ^{[1
]}

机构：

[1] Nihon Univ, Sch Pharm, Funabashi, Chiba 2748555, Japan

[2] Nihon Univ, Dept Chem, Coll Humanities & Sci, Tokyo 1568550, Japan

[3] Nihon Univ, Dept Gen Educ, Coll Humanities & Sci, Setagaya Ku, Tokyo 1568550, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2012年 / 60卷 / 03期

关键词：

Labiatae; Ziziphora clinopodioides; monoterpene glucoside; nitric oxide; macrophage; SCHIZONEPETA-TENUIFOLIA BRIQ; NITRIC-OXIDE; CONSTITUENTS; CELLS;

D O I：

10.1248/cpb.60.397

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new monoterpene glucosides, ziziphoroside A (1), B (2), and C (3), together with fifteen known compounds were isolated from the whole herb of Z. clinopodioides. The structures of new compounds were determined primarily from 1D-, 2D-NMR and circular dichroism (CD) spectroscopic analyses. The isolated compounds were evaluated for their inhibitory activity against nitric oxide (NO) production by lipopolysaccharide (LPS) and interferon (IFN)-gamma activated macrophages, RAW 264.7. Shizonepetoside A (8) and flavones (11, 12, 13) showed potent inhibitory activity against NO production.

引用

页码：397 / 401

页数：5

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