Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

被引:112
作者
Zamboulis, Alexandra [1 ]
Nanaki, Stavroula [1 ]
Michailidou, Georgia [1 ]
Koumentakou, Ioanna [1 ]
Lazaridou, Maria [1 ]
Ainali, Nina Maria [1 ]
Xanthopoulou, Eleftheria [1 ]
Bikiaris, Dimitrios N. [1 ]
机构
[1] Aristotle Univ Thessaloniki, Dept Chem, Lab Polymer Chem & Technol, Thessaloniki 54124, Greece
关键词
chitosan; derivatives; ocular drug delivery; ophthalmic applications; mucoadhesion; antibacterial; nanoparticles; hydrogels; coatings; IN-SITU GEL; NANOSTRUCTURED LIPID CARRIERS; OPHTHALMIC DRUG-DELIVERY; MUCOADHESIVE PROPERTIES; THERMOSENSITIVE HYDROGEL; CARBOXYMETHYL CHITOSAN; ANTIBACTERIAL ACTIVITY; CORNEAL PERMEATION; CONTACT-LENSES; POLYMERIC NANOPARTICLES;
D O I
10.3390/polym12071519
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.
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页数:67
相关论文
共 320 条
[51]   Sustained release of levofloxacin from thermosensitive chitosan-based hydrogel for the treatment of postoperative endophthalmitis [J].
Cheng, Yung-Hsin ;
Chang, Yu-Fan ;
Ko, Yu-Chieh ;
Liu, Catherine Jui-Ling .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2020, 108 (01) :8-13
[52]   Thermosensitive chitosan-gelatin-based hydrogel containing curcumin-loaded nanoparticles and latanoprost as a dual-drug delivery system for glaucoma treatment [J].
Cheng, Yung-Hsin ;
Ko, Yu-Chieh ;
Chang, Yu-Fan ;
Huang, Shu-Huei ;
Liu, Catherine Jui-ling .
EXPERIMENTAL EYE RESEARCH, 2019, 179 :179-187
[53]   Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment [J].
Cheng, Yung-Hsin ;
Tsai, Tung-Hu ;
Jhan, Yong-Yu ;
Chiu, Allen Wen-hsiang ;
Tsai, Kun-Ling ;
Chien, Chian-Shiu ;
Chiou, Shih-Hwa ;
Liu, Catherine Jui-Lin .
CARBOHYDRATE POLYMERS, 2016, 144 :390-399
[54]   Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions [J].
Chenite, A ;
Buschmann, M ;
Wang, D ;
Chaput, C ;
Kandani, N .
CARBOHYDRATE POLYMERS, 2001, 46 (01) :39-47
[55]   Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application [J].
Chhonker, Yashpal S. ;
Prasad, Yarra Durga ;
Chandasana, Hardik ;
Vishvkarma, Akhilesh ;
Mitra, Kalyan ;
Shukla, Praveen K. ;
Bhatta, Rabi S. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 72 :1451-1458
[56]   Staggered Herringbone Microfluid Device for the Manufacturing of Chitosan/TPP Nanoparticles: Systematic Optimization and Preliminary Biological Evaluation [J].
Chiesa, Enrica ;
Greco, Antonietta ;
Riva, Federica ;
Tosca, Elena Maria ;
Dorati, Rossella ;
Pisani, Silvia ;
Modena, Tiziana ;
Conti, Bice ;
Genta, Ida .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (24)
[57]   Poly(gamma-glutamic acid) based thermosetting hydrogels for injection: Rheology and functional parameters evaluation [J].
Chiesa, Enrica ;
Genta, Ida ;
Dorati, Rossella ;
Modena, Tiziana ;
Conti, Bice .
REACTIVE & FUNCTIONAL POLYMERS, 2019, 140 :93-102
[58]   Thermosensitive hexanoyl glycol chitosan-based ocular delivery system for glaucoma therapy [J].
Cho, Ik Sung ;
Park, Chun Gwon ;
Huh, Beom Kang ;
Cho, Myeong Ok ;
Khatun, Zehedina ;
Li, Zhengzheng ;
Kang, Sun-Woong ;
Bin Choy, Young ;
Huh, Kang Moo .
ACTA BIOMATERIALIA, 2016, 39 :124-132
[59]  
CHO IS, 2018, BIOMATER RES, V22, P1, DOI DOI 10.1186/S40824-018-0137-7
[60]   Advances and potential applications of chitosan derivatives as mucoadhesive biomaterials in modern drug delivery [J].
Chopra, Shruti ;
Mahdi, Saiqa ;
Kaur, Jasjeet ;
Iqbal, Zeenat ;
Talegaonkar, Sushma ;
Ahmad, Farhan J. .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2006, 58 (08) :1021-1032