Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.
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CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Acad Sci & Innovat Res AcSIR, New Delhi 110001, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Chhonker, Yashpal S.
;
Prasad, Yarra Durga
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CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Prasad, Yarra Durga
;
Chandasana, Hardik
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CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Acad Sci & Innovat Res AcSIR, New Delhi 110001, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Chandasana, Hardik
;
Vishvkarma, Akhilesh
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CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Rae BareLi 229010, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Vishvkarma, Akhilesh
;
Mitra, Kalyan
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CSIR Cent Drug Res Inst, Electron Microscopy Div, Lucknow 226031, Uttar Pradesh, India
Acad Sci & Innovat Res AcSIR, New Delhi 110001, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Mitra, Kalyan
;
Shukla, Praveen K.
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CSIR Cent Drug Res Inst, Med Mycol Div, Lucknow 226031, Uttar Pradesh, India
Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Rae BareLi 229010, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Shukla, Praveen K.
;
Bhatta, Rabi S.
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CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Rae BareLi 229010, India
Acad Sci & Innovat Res AcSIR, New Delhi 110001, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
机构:
Chungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Cho, Ik Sung
;
Park, Chun Gwon
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Seoul Natl Univ, Med Res Ctr, Inst Med & Biol Engn, Seoul 110799, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Park, Chun Gwon
;
Huh, Beom Kang
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Seoul Natl Univ, Coll Engn, Interdisciplinary Program Bioengn, Seoul 152742, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Huh, Beom Kang
;
Cho, Myeong Ok
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Chungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Korea Inst Toxicol, Next Generat Pharmaceut Res Ctr, Daejeon 341114, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Cho, Myeong Ok
;
Khatun, Zehedina
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Chungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Khatun, Zehedina
;
Li, Zhengzheng
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Chungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Tianjin Univ Sci & Technol, Coll Chem Engn & Mat Sci, Tianjin 300457, Peoples R ChinaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Li, Zhengzheng
;
Kang, Sun-Woong
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Korea Inst Toxicol, Next Generat Pharmaceut Res Ctr, Daejeon 341114, South Korea
Univ Sci & Technol, Human & Environm Toxicol Program, Daejeon 305350, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Kang, Sun-Woong
;
Bin Choy, Young
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Seoul Natl Univ, Med Res Ctr, Inst Med & Biol Engn, Seoul 110799, South Korea
Seoul Natl Univ, Coll Engn, Interdisciplinary Program Bioengn, Seoul 152742, South Korea
Seoul Natl Univ, Coll Med, Dept Biomed Engn, Seoul 110799, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
机构:
CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Acad Sci & Innovat Res AcSIR, New Delhi 110001, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Chhonker, Yashpal S.
;
Prasad, Yarra Durga
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CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Prasad, Yarra Durga
;
Chandasana, Hardik
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机构:
CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Acad Sci & Innovat Res AcSIR, New Delhi 110001, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Chandasana, Hardik
;
Vishvkarma, Akhilesh
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CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Rae BareLi 229010, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Vishvkarma, Akhilesh
;
Mitra, Kalyan
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h-index: 0
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CSIR Cent Drug Res Inst, Electron Microscopy Div, Lucknow 226031, Uttar Pradesh, India
Acad Sci & Innovat Res AcSIR, New Delhi 110001, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Mitra, Kalyan
;
Shukla, Praveen K.
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h-index: 0
机构:
CSIR Cent Drug Res Inst, Med Mycol Div, Lucknow 226031, Uttar Pradesh, India
Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Rae BareLi 229010, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Shukla, Praveen K.
;
Bhatta, Rabi S.
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机构:
CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Rae BareLi 229010, India
Acad Sci & Innovat Res AcSIR, New Delhi 110001, IndiaCSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India
机构:
Chungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Cho, Ik Sung
;
Park, Chun Gwon
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Seoul Natl Univ, Med Res Ctr, Inst Med & Biol Engn, Seoul 110799, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Park, Chun Gwon
;
Huh, Beom Kang
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Engn, Interdisciplinary Program Bioengn, Seoul 152742, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Huh, Beom Kang
;
Cho, Myeong Ok
论文数: 0引用数: 0
h-index: 0
机构:
Chungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Korea Inst Toxicol, Next Generat Pharmaceut Res Ctr, Daejeon 341114, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Cho, Myeong Ok
;
Khatun, Zehedina
论文数: 0引用数: 0
h-index: 0
机构:
Chungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Khatun, Zehedina
;
Li, Zhengzheng
论文数: 0引用数: 0
h-index: 0
机构:
Chungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Tianjin Univ Sci & Technol, Coll Chem Engn & Mat Sci, Tianjin 300457, Peoples R ChinaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Li, Zhengzheng
;
Kang, Sun-Woong
论文数: 0引用数: 0
h-index: 0
机构:
Korea Inst Toxicol, Next Generat Pharmaceut Res Ctr, Daejeon 341114, South Korea
Univ Sci & Technol, Human & Environm Toxicol Program, Daejeon 305350, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea
Kang, Sun-Woong
;
Bin Choy, Young
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Med Res Ctr, Inst Med & Biol Engn, Seoul 110799, South Korea
Seoul Natl Univ, Coll Engn, Interdisciplinary Program Bioengn, Seoul 152742, South Korea
Seoul Natl Univ, Coll Med, Dept Biomed Engn, Seoul 110799, South KoreaChungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea