Protein translocation as a tool: The current rapamycin story

被引：140

作者：

Putyrski, Mateusz ^{[1
]}

Schultz, Carsten ^{[1
]}

机构：

[1] EMBL Heidelberg, Cell Biol & Biophys Unit, D-69117 Heidelberg, Germany

来源：

FEBS LETTERS | 2012年 / 586卷 / 15期

关键词：

Rapamycin; Chemical dimerizer; Protein-protein interaction; Protein translocation; Signal transduction; SIGNAL-TRANSDUCTION; CHEMICAL INDUCER; PLASMA-MEMBRANE; BINDING DOMAIN; ACTIVATION; KINASE; GROWTH; CELLS; DIMERIZATION; RECRUITMENT;

D O I：

10.1016/j.febslet.2012.04.061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2097 / 2105

页数：9

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