The Human Gut Microbiota and Undernutrition

被引：133

作者：

Gordon, Jeffrey I. ^{[1
]}

Dewey, Kathryn G. ^{[2
]}

Mills, David A. ^{[3
,4
,5
]}

Medzhitov, Ruslan M. ^{[6
,7
]}

机构：

[1] Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA

[2] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA

[3] Univ Calif Davis, Dept Viticulture & Enol, Davis, CA 95616 USA

[4] Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA

[5] Univ Calif Davis, Foods Hlth Inst, Davis, CA 95616 USA

[6] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[7] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 137期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

HUMAN-MILK; GROWTH-FACTOR; NUTRITION; CYTOKINES; PATTERNS; PROTEIN; IMPACT; ALPHA; ACIDS; TERM;

D O I：

10.1126/scitranslmed.3004347

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Childhood malnutrition is a global health problem that cannot be attributed to food insecurity alone. The gut microbiota may contribute to this devastating health disorder. In this Perspective, we call for the application of tools and concepts emerging from studies of the human gut microbiota to better understand the nutritional needs of infants and children and the role of the microbiota in the pathogenesis and treatment of undernutrition. This effort will require elucidation of the interrelationships between breast milk composition and the development of the microbiota and immune system in the context of the maternal-infant dyad.

引用

页数：6

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