Multivalent calixarene-based C-fucosyl derivative: a new Pseudomonas aeruginosa biofilm inhibitor

被引：36
作者：
Consoli, Grazia M. L. [1 ]
Granata, Giuseppe [1 ]
Cafiso, Viviana [2 ]
Stefani, Stefania [2 ]
Geraci, Corrada [1 ]
机构：
[1] CNR, Ist Chim Biomol, I-95126 Catania, Italy
[2] Univ Catania, Dipartimento Sci Biomed Sez Microbiol, I-95124 Catania, Italy
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 44期
关键词：
C-Fucosyl derivative; Calixarene; Pseudomonas aeruginosa; Inhibition biofilm assay; Multivalency; LECTIN PA-IIL; BINDING-PROPERTIES; BACTERIAL LECTIN; HIGH-AFFINITY; THERMODYNAMICS; GLYCOCLUSTERS; SPECIFICITY; DESIGN; LECB; IL;
D O I：
10.1016/j.tetlet.2011.08.142
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first example of multivalent conjugate in which four alpha-L-C-fucosyl units are clustered by means of a calix[4]arene platform was designed as a new potential Pseudomonas aeruginosa biofilm inhibitor. The anti-biofilm activity of the synthesized compound (6) against PAO1 strain was assayed and it was found to be dose-dependent. The presence of the fucose cluster improves the biofilm inhibitor efficiency as proven by the lower inhibitor activity of the analogous glycyl-calix[4]arene derivative (3) lacking in the fucose moieties. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5831 / 5834
页数：4
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