Identifying the Therapeutic Significance of Mesenchymal Stem Cells

被引：136
作者：
Mishra, Vineet Kumar
Shih, Hui-Hsuan
Parveen, Farzana
Lenzen, David
Ito, Etsuro
Chan, Te-Fu
Ke, Liang-Yin
机构：
[1] Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung
[2] Center for Lipid Biosciences, Kaohsiung Medical University Hospital, Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung
[3] Division of Chest Medicine, Department of International Medicine, MacKay Memorial Hospital, Taipei
[4] Graduate Institute of Medicine, College of Medicine & Drug Development, Value Creation Research Center, Kaohsiung Medical University, Kaohsiung
[5] Department of Biology, Waseda University, Tokyo
[6] Waseda Research Institute for Science and Engineering, Waseda University, Tokyo
[7] Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung
来源：
CELLS | 2020年 / 9卷 / 05期
关键词：
mesenchymal stem cell (MSC); microenvironment; immunosuppression; immunomodulation; adipogenesis; type; 2; diabetes; VERSUS-HOST-DISEASE; MARROW STROMAL CELLS; TYPE-2; DIABETES-MELLITUS; UMBILICAL-CORD BLOOD; HUMAN ADIPOSE-TISSUE; INSULIN-PRODUCING CELLS; SUPPRESS T-LYMPHOCYTE; MOUSE MODEL; IN-VITRO; PROSTAGLANDIN E-2;
D O I：
10.3390/cells9051145
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due to their immense potential for immunosuppression and their therapeutic role in immune disorders. MSCs migrate towards inflamed microenvironments, produce anti-inflammatory cytokines and conceal themselves from the innate immune system. These signatures are the reason for the uprising in the sciences of cellular therapy in the last decades. Irrespective of their therapeutic role in immune disorders, some factors limit beneficial effects such as inconsistency of cell characteristics, erratic protocols, deviating dosages, and diverse transfusion patterns. Conclusive protocols for cell culture, differentiation, expansion, and cryopreservation of MSCs are of the utmost importance for a better understanding of MSCs in therapeutic applications. In this review, we address the immunomodulatory properties and immunosuppressive actions of MSCs. Also, we sum up the results of the enhancement, utilization, and therapeutic responses of MSCs in treating inflammatory diseases, metabolic disorders and diabetes.
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页数：30
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