Catalyst-Free Intermolecular Sulfonyl/Fluoromethyl Heteroarylation of Vinyl Ethers via Visible-Light-Induced Charge Transfer

被引：6

作者：

Long, Tianyu ^{[1
]}

Pan, Shiwei ^{[1
]}

Zhu, Shengqing ^{[1
]}

Chu, Lingling ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Ctr Adv Low Dimens Mat, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2022年 / 28卷 / 15期

基金：

中国国家自然科学基金;

关键词：

alkenes; catalyst-free reactions; difunctionalization; electron-donor-acceptor complex; radical cascade; DONOR-ACCEPTOR COMPLEX; ARYLATION; ALKYLATION; FLUORINE; ROUTES; DRIVEN;

D O I：

10.1002/chem.202104080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a visible-light-induced three-component sulfonyl-heteroarylation of vinyl ethers with sulfinates and five-membered heteroaryl chlorides. This protocol proceeds via electron-donor-acceptor (EDA) complexes between sulfinates and heteroaryl chlorides, giving beta-sulfonyl alkyl five-membered heteroarenes with high efficiency and excellent regioselectivity under mild and catalyst-free conditions. Utilization of CF3SO2Na or CF2HSO2Na as coupling partners further achieves three-component fluoromethyl-arylation of vinyl ethers, furnishing a series of valuable CF3/CF2H-incorporated alkyl heterocycles under mild conditions.

引用

页数：6

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