Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy

被引：21

作者：

Jin, Xun ^{[1
,2
,3
]}

Zou, Bingwen ^{[4
]}

Luo, Li ^{[1
,2
,3
]}

Zhong, Chuanhong ^{[5
]}

Zhang, Peilan ^{[1
,2
,3
]}

Cheng, Hao ^{[1
,2
,3
]}

Guo, Yanfang ^{[1
,2
,3
]}

Gou, Maling ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Ctr Canc, Chengdu 610041, Peoples R China

[3] Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China

[4] Sichuan Univ, West China Hosp, Sch Med, Dept Thorac Oncol,Canc Ctr, Chengdu, Peoples R China

[5] Luzhou Med Coll, Affiliated Hosp, Dept Neurosurg, Luzhou, Sichuan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2016年 / 11卷

关键词：

thioridazine; doxorubicin; codelivery; nanoparticles; breast cancer; DRUG-DELIVERY; CO-DELIVERY; NANOTECHNOLOGY; PERMEABILITY; CHEMOTHERAPY; SIZE;

D O I：

10.2147/IJN.S104635

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Cancer chemotherapy can benefit from the combination of different anticancer drugs. Here, we prepared doxorubicin (Dox)- and thioridazine (Thio)-coloaded methoxy poly(ethylene glycol)-poly(L-lactic acid) (MPEG-PLA) nanoparticles (NPs) for breast cancer therapy. These NPs have an average particle size of 27 nm. The drug loading efficiencies of Thio and Dox are 4.71% and 1.98%, respectively. Compared to the treatment of Thio or Dox alone, the combination of Thio and Dox exhibited a synergistic effect in inhibiting the growth of 4T1 breast cancer cells in vitro. In addition, the Thio- and Dox-coloaded MPEG-PLA NPs could efficiently suppress the growth of breast cancer cells in vivo. This study suggests that Thio-and Dox-coloaded MPEG-PLA NPs might have potential applications in breast cancer treatment.

引用

页码：4545 / 4552

页数：8

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