Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol

被引：134

作者：

Lee, Bomi ^{[1
,2
]}

Shin, Yong-Wook ^{[1
,2
]}

Bae, Eun-Ah ^{[1
,2
]}

Han, San-Jun ^{[1
,2
]}

Kim, Joo-Sun ^{[3
]}

Kang, Sam-Sik ^{[3
]}

Kim, Dong-Hyun ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[2] Kyung Hee Univ, Dept Pharmaceut Sci, Seoul 130701, South Korea

[3] Seoul Natl Univ, Inst Nat Prod, Seoul 110460, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 04期

关键词：

allergy; Paeonia lactiflora; paeoniflorin; paeonol;

D O I：

10.1007/s12272-001-1177-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The root of Paeonia lactiflora PALL (PL, Family Paeoniaceae) has been used frequently as an antipyretic and anti-inflammatory agent in traditional medicines of Korea, China and Japan. To evaluate antiallergic effect of PL, we isolated its main constituents, paeoniflorin and paeonol, and evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors induced by compound 48/80. PL, paeoniflorin and paeonol potently inhibited PCA reaction and scratching behaviors in mice. Paeoniflorin exhibited the most potent inhibition against scratching behaviors and the acetic acid-induced writhing syndrome in mice. Paeonol most potently inhibited PCA reaction and mast cells degranulation. These findings suggest that PL can improve IgE-induced anaphylaxis and scratching behaviors, and may be due to the effect of its constituents, paeoniflorin and paeonol.

引用

页码：445 / 450

页数：6

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