Translational Neuroscience of Schizophrenia: Seeking a Meeting of Minds Between Mouse and Man

被引：15
作者：
Kas, Martien J. [1 ]
Kahn, Rene S. [2 ]
Collier, David A. [3 ]
Waddington, John L. [4 ]
Ekelund, Jesper [5 ,6 ,14 ]
Porteous, David J. [7 ]
Schughart, Klaus [8 ,9 ]
Hovatta, Iiris [10 ,11 ,12 ,13 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Neurosci & Pharmacol, NL-3584 CG Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3584 CX Utrecht, Netherlands
[3] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
[4] Royal Coll Surgeons Ireland, Dublin 2, Ireland
[5] Univ Helsinki, Dept Psychiat, Vaasa Hosp Dist, Helsinki 00251, Finland
[6] Natl Inst Hlth & Welf, Mental Hlth Serv, Helsinki 00251, Finland
[7] Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, Ctr Mol Med,Med Genet Sect, Edinburgh EH4 2XU, Midlothian, Scotland
[8] Helmholtz Ctr Infect Res, Dept Infect Genet, D-38124 Braunschweig, Germany
[9] Univ Vet Med Hannover, D-38124 Braunschweig, Germany
[10] Univ Helsinki, Biomedicum Helsinki, Res Programs Unit, FIN-00290 Helsinki, Finland
[11] Univ Helsinki, Dept Med Genet, Haartman Inst, FIN-00290 Helsinki, Finland
[12] Natl Inst Hlth & Welf, Mental Hlth Serv, Helsinki 00300, Finland
[13] Natl Inst Hlth & Welf, Subst Abuse Serv, Helsinki 00300, Finland
[14] Natl Inst Hlth & Welf, Subst Abuse Serv, Helsinki 00251, Finland
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2011年 / 3卷 / 102期
关键词：
QUANTITATIVE TRAIT LOCI; GENETIC RISK SCORE; 1ST-EPISODE SCHIZOPHRENIA; PREPULSE INHIBITION; COMMON VARIANTS; BRAIN VOLUME; MICE; NEUREGULIN-1; ASSOCIATION; TWIN;
D O I：
10.1126/scitranslmed.3002917
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Understanding the etiology of developmental brain disorders such as schizophrenia is critical for achieving advances in treatment and requires new research strategies that control for individual variation in genetic background, environmental challenges, and expression of phenotype. SYSGENET, a European systems genetics network for the study of complex genetic human diseases with mouse genetic reference populations, brought together in Helsinki a cross-disciplinary group of clinical and basic scientists and mouse geneticists to debate, formulate, and prioritize a strategy for future research based on mouse models. The main conclusions of this meeting are summarized here.
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