Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children

被引：25

作者：

Nie, Linda H. ^{[1
]}

Wright, Robert O. ^{[2
,3
]}

Bellinger, David C. ^{[3
]}

Hussain, Javed ^{[3
]}

Amarasiriwardena, Chitra ^{[2
]}

Chettle, David R. ^{[4
]}

Pejovic-Milic, Ana ^{[5
]}

Woolf, Alan ^{[3
]}

Shannon, Michael ^{[3
]}

机构：

[1] Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA

[2] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[3] Childrens Hosp, Boston, MA 02115 USA

[4] McMaster Univ, Hamilton, ON, Canada

[5] Ryerson Univ, Toronto, ON, Canada

来源：

BIOMARKERS | 2011年 / 16卷 / 06期

关键词：

Heavy metal toxicity; neurological disease; environmental pollution/ecotoxicology; X-RAY-FLUORESCENCE; BONE LEAD; INTELLECTUAL FUNCTION; ENDOGENOUS RELEASE; KINETIC-MODEL; EXPOSURE; ADULTS; CHILDHOOD;

D O I：

10.3109/1354750X.2011.604133

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: To find the best lead exposure assessment marker for children. Methods: We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level. Results: Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score. Conclusion: Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.

引用

页码：517 / 524

页数：8

共 24 条

[1] BARRY PSI, 1970, BRIT J IND MED, V27, P339
[2] Evaluation of a novel structural model to describe the endogenous release of lead from bone
Brito, JAA
McNeill, FE
Webber, CE
Wells, S
Richard, N
Carvalho, ML
Chettle, DR
[J]. JOURNAL OF ENVIRONMENTAL MONITORING, 2002, 4 (02): : 194 - 201
[3] Bone, blood and semen lead in men with environmental and moderate occupational exposure
Farias, P
Echavarria, M
Hernandez-Avila, M
Villanueva, C
Amarasiriwardena, C
Hernandez, L
Aro, A
Hu, H
[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, 2005, 15 (01) : 21 - 31
[4] Accumulated body burden and endogenous release of lead in employees of a lead smelter
Fleming, DEB
Boulay, D
Richard, NS
Robin, JP
Gordon, CL
Webber, CE
Chettle, DR
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1997, 105 (02) : 224 - 233
[5] LEAD-POISONING FROM MOBILIZATION OF BONE STORES DURING THYROTOXICOSIS
GOLDMAN, RH
WHITE, R
KALES, SN
HU, H
[J]. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 1994, 25 (03) : 417 - 424
[6] A noninvasive isotopic approach to estimate the bone lead contribution to blood in children: Implications for assessing the efficacy of lead abatement
Gwiazda, R
Campbell, C
Smith, D
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (01) : 104 - 110
[7] Evaluation of uncertainty and detection limits in radioactivity measurements
Herranz, M.
Idoeta, R.
Legarda, F.
[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2008, 595 (02) : 526 - 534
[8] BONE LEAD MEASURED BY X-RAY-FLUORESCENCE - EPIDEMIOLOGIC METHODS
HU, H
ARO, A
ROTNITZKY, A
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1995, 103 : 105 - 110
[9] *ICRP, 1996, SKELETON ANN ICRP, V25, P36
[10] Low-level environmental lead exposure and children's intellectual function: An international pooled analysis
Lanphear, BP
Hornung, R
Khoury, J
Yolton, K
Baghurstl, P
Bellinger, DC
Canfield, RL
Dietrich, KN
Bornschein, R
Greene, T
Rothenberg, SJ
Needleman, HL
Schnaas, L
Wasserman, G
Graziano, J
Roberts, R
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (07) : 894 - 899

← 1 2 3 →