Skeletal Analogues of UCS1025A and B by Cyclization of Maleimides: Synthesis and Biological Activity

被引：2

作者：

Ibbotson, Lewis T. ^{[1
]}

Christensen, Kirsten E. ^{[1
]}

Genov, Miroslav ^{[2
]}

Pretsch, Alexander ^{[2
]}

Pretsch, Dagmar ^{[2
]}

Moloney, Mark G. ^{[1
,3
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England

[2] Oxford Antibiot Grp, Magdalen Ctr, Oxford Sci Pk, Oxford OX4 4GA, England

[3] Oxford Suzhou Ctr Adv Res, Bldg A,388 Ruo Shui Rd,Suzhou Ind Pk, Suzhou 215123, Jiangsu, Peoples R China

来源：

SYNLETT | 2022年 / 33卷 / 04期

关键词：

lactams; aldol reaction; ketene silyl ether; cyclization; antibiotics; ANTIBIOTICS; CJ-16,264; SCAFFOLDS; FAMILY; ACIDS;

D O I：

10.1055/s-0040-1719876

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Application of a direct ring-closing approach which exploits an intramolecular aldol reaction with a ketene silyl acetal onto a remote imide function leading to the core skeleton of UCS1025A and B effectively provides access to small library of substituted analogues; of interest is their complete lack of antibacterial activity against MRSA (Gram+) and E. coli (Gram-) bacterial strains. © 2022 Georg Thieme Verlag. All rights reserved.

引用

页码：396 / 400

页数：5

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