Case Report: Severe Acute Pulmonary COVID-19 in a Teenager Post Autologous Hematopoietic Stem Cell Transplant

被引：1

作者：

van der Velden, Fabian J. S. ^{[1
,2
]}

van Delft, Frederik ^{[3
]}

Owens, Stephen ^{[1
]}

Llevadias, Judit ^{[4
]}

McKean, Michael ^{[5
]}

Pulford, Lindsey ^{[4
]}

Taha, Yusri ^{[6
]}

Williamson, Grace ^{[7
]}

Campbell-Hewson, Quentin ^{[3
]}

Hambleton, Sophie ^{[1
,2
]}

Payne, Rebecca ^{[2
]}

Duncan, Christopher ^{[2
,8
]}

Johnston, Catriona ^{[9
]}

Spegarova, Jarmila ^{[2
]}

Emonts, Marieke ^{[1
,2
]}

机构：

[1] Great North Childrens Hosp, Newcastle Tyne Hosp NHS Fdn Trust, Paediat Immunol Infect Dis & Allergy, Newcastle Upon Tyne, Northumberland, England

[2] Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Newcastle Upon Tyne, Northumberland, England

[3] Great North Childrens Hosp, Newcastle Tyne Hosp NHS Fdn Trust, Paediat Oncol, Newcastle Upon Tyne, Northumberland, England

[4] Newcastle Tyne Hosp NHS Fdn Trust, Freeman Hosp, Paediat Intens Care, Newcastle Upon Tyne, Northumberland, England

[5] Great North Childrens Hosp, Newcastle Tyne Hosp NHS Fdn Trust, Paediat Resp Dept, Newcastle Upon Tyne, Tyne & Wear, England

[6] Newcastle Tyne Hosp NHS Fdn Trust, Virol, Newcastle Upon Tyne, Northumberland, England

[7] Great North Childrens Hosp, Newcastle Upon Tyne Hosp NHS Fdn Trust, Paediat Intens Care, Newcastle Upon Tyne, Tyne & Wear, England

[8] Newcastle Tyne Hosp NHS Fdn Trust, Infect Dis & Trop Med, Newcastle Upon Tyne, Tyne & Wear, England

[9] Newcastle Upon Tyne Hosp NHS Fdn Trust, Pharm, Newcastle Upon Tyne, Tyne & Wear, England

来源：

FRONTIERS IN PEDIATRICS | 2022年 / 10卷

基金：

欧盟地平线“2020”;

关键词：

pediatric; COVID-19; stem cell transplant; immunomodulation; immunodeficient; ORGANIZING PNEUMONIA; ASSOCIATION; RECIPIENTS; MORTALITY;

D O I：

10.3389/fped.2022.809061

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Pulmonary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children is generally described as mild, and SARS-CoV-2 infection in immunocompromised children are observed as generally mild as well. A small proportion of pediatric patients will become critically ill due to (cardio)respiratory failure and require intensive care treatment. We report the case of a teenager with Hodgkin's lymphoma who acquired SARS-CoV-2 (detected by PCR) on the day of her autologous stem cell transplant and developed acute respiratory distress syndrome, successfully treated with a combination of antivirals, immunomodulation with steroids and biologicals, and ECMO.

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页数：8

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