Synthesis, DNA binding and cleavage activities of copper (II) thiocyanate complex with 4-(N,N-dimethylamino)pyridine and N,N-dimethylformamide

被引：12

作者：

Chen, Feng-juan

Xu, Min

Xi, Pin-xian

Liu, Hong-yang

Zeng, Zheng-zhi ^{[1
]}

机构：

[1] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2011年 / 81卷 / 01期

关键词：

Copper(II) complex; 4-(N; N-dimethylamino)pyridine; DNA-binding; Cleavage; RUTHENIUM(II) COMPLEXES; NUCLEASE ACTIVITY; RECOGNITION; LIGAND; PHOTOCLEAVAGE; DESIGN; TRIS(PHENANTHROLINE)RUTHENIUM(II); RHODIUM(III); CHEMISTRY; ACID;

D O I：

10.1016/j.saa.2011.05.020

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Two novel copper(II) thiocyanate complexes with 4-(N,N-dimethylamino) pyridine and N,N-dimethylformamide(1) and with4-(N,N-dimethylamino) pyridine (2) have been synthesized and characterized. The crystal and molecular structures of complexes 1 and 2 were determined by single-crystal X-ray diffraction. Antioxidative activity tests in vitro showed that complex 1 has significant antioxidative activity against hydroxyl free radicals from the Fenton reaction and also oxygen free radicals, which is better than standard antioxidants like vitamin C and mannitol. The interaction of complex 1 with calf thymus DNA was investigated by spectroscopic, cyclic voltammetry, and viscosity measurements. Results suggest that complex 1 can bind to DNA via partial intercalation mode. Moreover, complex 1 has been found to cleavage of plasmid DNA pBR322. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：21 / 27

页数：7

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