The Emergence of lncRNAs in Cancer Biology

被引：1591

作者：

Prensner, John R. ^{[1
,2
]}

Chinnaiyan, Arul M. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Michigan, Sch Med, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Sch Med, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

来源：

CANCER DISCOVERY | 2011年 / 1卷 / 05期

关键词：

LONG NONCODING RNA; INACTIVE X-CHROMOSOME; BECKWITH-WIEDEMANN-SYNDROME; METHYLATED HISTONE H3; GENE-EXPRESSION; BREAST-CANCER; HUMAN GENOME; DISTINCT CLASSES; PROSTATE-CANCER; IMPRINTED GENES;

D O I：

10.1158/2159-8290.CD-11-0209

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to mammals has dramatically altered our understanding of cell biology, especially the biology of diseases such as cancer. In humans, the identification of abundant long ncRNA (lncRNA) >200 bp has catalyzed their characterization as critical components of cancer biology. Recently, roles for lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared in prevalent cancer types, such as breast and prostate cancer. In this review, we highlight the emerging impact of ncRNAs in cancer research, with a particular focus on the mechanisms and functions of lncRNAs. Significance: lncRNAs represent the leading edge of cancer research. Their identity, function, and dysregulation in cancer are only beginning to be understood, and recent data suggest that they may serve as master drivers of carcinogenesis. Increased research on these RNAs will lead to a greater understanding of cancer cell function and may lead to novel clinical applications in oncology. Cancer Discovery;1(5):391-407. (C) 2011 AACR.

引用

页码：391 / 407

页数：17

共 104 条

[1] 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC [J].

Ahmadiyeh, Nasim ;

Pomerantz, Mark M. ;

Grisanzio, Chiara ;

Herman, Paula ;

Jia, Li ;

Almendro, Vanessa ;

He, Housheng Hansen ;

Brown, Myles ;

Liu, X. Shirley ;

Davis, Matt ;

Caswell, Jennifer L. ;

Beckwith, Christine A. ;

Hills, Adam ;

MacConaill, Laura ;

Coetzee, Gerhard A. ;

Regan, Meredith M. ;

Freedman, Matthew L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (21) :9742-9746

[2] The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis [J].

Barsyte-Lovejoy, Dalia ;

Lau, Suzanne K. ;

Boutros, Paul C. ;

Khosravi, Fereshteh ;

Jurisica, Igor ;

Andrulis, Irene L. ;

Tsao, Ming S. ;

Penn, Linda Z. .

CANCER RESEARCH, 2006, 66 (10) :5330-5337

[3] PARENTAL IMPRINTING OF THE MOUSE H19 GENE [J].

BARTOLOMEI, MS ;

ZEMEL, S ;

TILGHMAN, SM .

NATURE, 1991, 351 (6322) :153-155

[4] Ultraconserved elements in the human genome [J].

Bejerano, G ;

Pheasant, M ;

Makunin, I ;

Stephen, S ;

Kent, WJ ;

Mattick, JS ;

Haussler, D .

SCIENCE, 2004, 304 (5675) :1321-1325

[5] CpG methylation analysis of the MEG3 and SNRPN imprinted genes in acute myeloid leukemia and myelodysplastic syndromes [J].

Benetatos, Leonidas ;

Hatzimichael, Eleftheria ;

Dasoula, Aggeliki ;

Dranitsaris, George ;

Tsiara, Stavroula ;

Syrrou, Maria ;

Georgiou, Ioannis ;

Bourantas, Konstantinos L. .

LEUKEMIA RESEARCH, 2010, 34 (02) :148-153

[6] A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression [J].

Bernard, Delphine ;

Prasanth, Kannanganattu V. ;

Tripathi, Vidisha ;

Colasse, Sabrina ;

Nakamura, Tetsuya ;

Xuan, Zhenyu ;

Zhang, Michael Q. ;

Sedel, Frederic ;

Jourdren, Laurent ;

Coulpier, Fanny ;

Triller, Antoine ;

Spector, David L. ;

Bessis, Alain .

EMBO JOURNAL, 2010, 29 (18) :3082-3093

[7] Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin [J].

Bernstein, E ;

Duncan, EM ;

Masui, O ;

Gil, J ;

Heard, E ;

Allis, CD .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (07) :2560-2569

[8] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project [J].

Birney, Ewan ;

Stamatoyannopoulos, John A. ;

Dutta, Anindya ;

Guigo, Roderic ;

Gingeras, Thomas R. ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Snyder, Michael ;

Dermitzakis, Emmanouil T. ;

Stamatoyannopoulos, John A. ;

Thurman, Robert E. ;

Kuehn, Michael S. ;

Taylor, Christopher M. ;

Neph, Shane ;

Koch, Christoph M. ;

Asthana, Saurabh ;

Malhotra, Ankit ;

Adzhubei, Ivan ;

Greenbaum, Jason A. ;

Andrews, Robert M. ;

Flicek, Paul ;

Boyle, Patrick J. ;

Cao, Hua ;

Carter, Nigel P. ;

Clelland, Gayle K. ;

Davis, Sean ;

Day, Nathan ;

Dhami, Pawandeep ;

Dillon, Shane C. ;

Dorschner, Michael O. ;

Fiegler, Heike ;

Giresi, Paul G. ;

Goldy, Jeff ;

Hawrylycz, Michael ;

Haydock, Andrew ;

Humbert, Richard ;

James, Keith D. ;

Johnson, Brett E. ;

Johnson, Ericka M. ;

Frum, Tristan T. ;

Rosenzweig, Elizabeth R. ;

Karnani, Neerja ;

Lee, Kirsten ;

Lefebvre, Gregory C. ;

Navas, Patrick A. ;

Neri, Fidencio ;

Parker, Stephen C. J. ;

Sabo, Peter J. ;

Sandstrom, Richard ;

Shafer, Anthony .

NATURE, 2007, 447 (7146) :799-816

[9] Increased tumour risk for BWS patients correlates with aberrant H19 and not KCNQ1OT1 methylation:: occurrence of KCNQ1OT1 hypomethylation in familial cases of BWS [J].

Bliek, J ;

Maas, SM ;

Ruijter, JM ;

Hennekam, RCM ;

Alders, M ;

Westerveld, A ;

Mannens, MMAM .

HUMAN MOLECULAR GENETICS, 2001, 10 (05) :467-476

[10] Paraspeckles: nuclear bodies built on long noncoding RNA [J].

Bond, Charles S. ;

Fox, Archa H. .

JOURNAL OF CELL BIOLOGY, 2009, 186 (05) :637-644

← 1 2 3 4 5 6 7 8 9 10 →