Switching Anti-VEGF Drugs in the Treatment of Diabetic Macular Edema

被引：26

作者：

Banaee, Touka ^{[1
]}

Ashraf, Mohammed ^{[2
]}

Conti, Felipe F. ^{[3
]}

Singh, Rishi P. ^{[3
]}

机构：

[1] Mashhad Univ Med Sci, Mashhad, Iran

[2] Alexandria Univ, Alexandria, Egypt

[3] Cole Eye Inst, Cleveland, OH USA

来源：

OPHTHALMIC SURGERY LASERS & IMAGING RETINA | 2017年 / 48卷 / 09期

关键词：

OPTICAL COHERENCE TOMOGRAPHY; RETINAL THICKNESS MEASUREMENTS; SHORT-TERM OUTCOMES; INTRAVITREAL AFLIBERCEPT; RANIBIZUMAB THERAPY; BEVACIZUMAB; TACHYPHYLAXIS; CONVERSION; REPRODUCIBILITY; PATHOGENESIS;

D O I：

10.3928/23258160-20170829-10

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Since their introduction in the late 2000s, anti-vascular endothelial growth factor (VEGF) agents have become the first-line choice for center-involved diabetic macular edema (DME). Even with its proven effectiveness, there are still cases that do not respond satisfactorily. In those cases, a treatment option is to change to another anti-VEGF drug. In this paper, the authors review studies on switching between different anti-VEGF drugs in the treatment of persistent DME. An extensive bibliographic review was done using PubMed, Embase, and Scopus. Fourteen studies published from March 2010 to April 2017 reporting switching from anti-VEGF drugs in DME treatment were included. All reported good anatomical results after conversion; however, visual acuity outcomes showed great variability between publications. Therefore, switching to other anti-VEGFs in patients with DME not responding to previous anti-VEGF therapy may be an option, but the results are still not well-known due to a lack of randomized clinical trials.

引用

页码：748 / 754

页数：7

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