Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B

被引：17
作者：
Rajendran, V
Rong, SB
Saxena, A
Doctor, BP
Kozikowski, AP
机构：
[1] Georgetown Univ, Med Ctr, Dept Neurol, Drug Discovery Program, Washington, DC 20007 USA
[2] Walter Reed Army Inst Res, Div Biochem, Washington, DC 20307 USA
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 32期
关键词：
D O I：
10.1016/S0040-4039(01)01008-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5359 / 5361
页数：3
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