Ebola Virus Disease and Current Therapeutic Strategies: A Review

被引：4

作者：

Diakou, Kalliopi Io ^{[1
]}

Mitsis, Thanasis ^{[1
]}

Pierouli, Katerina ^{[1
]}

Papakonstantinou, Eleni ^{[1
]}

Bongcam-Rudloff, Erik ^{[2
]}

Wayengera, Misaki ^{[3
]}

Vlachakis, Dimitrios ^{[4
,5
,6
]}

机构：

[1] Agr Univ Athens, Sch Appl Biol & Biotechnol, Dept Biotechnol, Lab Genet, Athens, Greece

[2] Univ Agr Sci Uppsala, SLU Global Bioinformat Ctr, Dept Anim Breeding & Genet Sci, Uppsala, Sweden

[3] Makerere Univ, Sch Biomed Sci, Dept Pathol, Unit Genet & Genom,Coll Hlth Sci, Kampala, Uganda

[4] Agr Univ Athens, Sch Appl Biol & Biotechnol, Dept Biotechnol, DarkDNA Grp,Lab Genet, Athens, Greece

[5] Acad Athens, Biomed Res Fdn, Lab Mol Endocrinol, Ctr Clin Expt Surg & Translat Res, Athens, Greece

[6] Kings Coll London, Fac Nat & Math Sci, Dept Informat, London, England

来源：

GENEDIS 2020: GENETICS AND NEURODEGENERATIVE DISEASES | 2021年 / 1339卷

基金：

欧盟地平线“2020”;

关键词：

Ebola virus; Infectious disease; Epidemiology; Treatment; MARBURG; EVOLUTION;

D O I：

10.1007/978-3-030-78787-5_18

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Ebola virus disease is a severe hemorrhagic fever that affects humans and other primates. Ebola virus, the causative agent of the disease, is transmitted to humans from wild animals and is highly contagious and aggressive with an estimated fatality rate to be around 50%. Since 1976, 11 outbreaks of Ebola virus disease have been reported in total, affecting mostly sub-Saharan Africa, while the most recent ongoing outbreak in the Democratic Republic of the Congo has more than 3000 reported cases and 72 deaths. Although an effective vaccine against Ebola virus disease has become available, no targeted treatment with proven efficacy upon infection is developed. Herein, we review the epidemiology of Ebola virus and the current situation in terms of prevention, diagnosis, and treatment of the disease.

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页数：7

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