Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis

被引：83
作者：
Overeem, S
Dalmau, J
Bataller, L
Nishino, S
Mignot, E
Verschuuren, J
Lammers, GJ
机构：
[1] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands
[2] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
[3] Univ Hosp La Fe, Dept Neurol, Valencia, Spain
[4] Stanford Univ, Ctr Narcolepsy, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA
来源：
NEUROLOGY | 2004年 / 62卷 / 01期
关键词：
D O I：
10.1212/01.WNL.0000101718.92619.67
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with ideopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.
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收藏
页码：138 / 140
页数：3
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