Construction of a new luminescent Cd(ii) compound for the detection of Fe3+ and treatment of Hepatitis B

A novel porous Cd(ii) metal-organic framework (MOF) with the chemical composition of {[H3O][Cd(bci)]}( n )center dot 2n(H2O) (1, H(3)bci = bis(2-carboxyethyl)isocyanurate) was prepared via hydrothermal responses of H(3)bci and Cd(NO3)(2)center dot 4H(2)O. Luminescent property investigations indicated that compound 1 had high sensitivity toward Fe3+, and the detection limit of Fe3+ was as low as 2.15 x 10(-4) M. The application values of Fe3+ on Hepatitis B were assessed, and its associated mechanism was identified simultaneously. First, the cytotoxic mediator (TNF-alpha) substance released into plasma was measured through the ELISA. In addition, real-time RT-PCR was employed to determine the Hepatitis B viral replication gene relative expression levels. Finally, the novel compound's toxicity against human normal liver cells was tested by using the CCK-8 assay.