Nitric Oxide Donors Enhance the Frequency Dependence of Dopamine Release in Nucleus Accumbens

被引:32
作者
Hartung, Henrike [1 ,2 ,3 ]
Threlfell, Sarah [2 ,3 ]
Cragg, Stephanie J. [2 ,3 ]
机构
[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
[2] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QT, England
[3] Univ Oxford, Oxford Parkinsons Dis Ctr, Oxford OX1 3QT, England
基金
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词
nitric oxide; acetylcholine; dopamine; striatal cholinergic interneurons; nucleus accumbens; voltammetry; TONICALLY ACTIVE NEURONS; IN-VIVO MICRODIALYSIS; FREELY MOVING RAT; NEOSTRIATAL CHOLINERGIC INTERNEURONS; VENTRAL SUBICULAR AFFERENTS; NUCLEOTIDE-GATED CHANNEL; LONG-TERM DEPRESSION; MIDBRAIN DOPAMINE; CAUDATE-PUTAMEN; STRIATAL DOPAMINE;
D O I
10.1038/npp.2011.62
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dopamine (DA) neurotransmission in the nucleus accumbens (NAc) is critically involved in normal as well as maladaptive motivated behaviors including drug addiction. Whether the striatal neuromodulator nitric oxide (NO) influences DA release in NAc is unknown. We investigated whether exogenous NO modulates DA transmission in NAc core and how this interaction varies depending on the frequency of presynaptic activation. We detected DA with cyclic voltammetry at carbon-fiber microelectrodes in mouse NAc in slices following stimuli spanning a full range of DA neuron firing frequencies (1-100 Hz). NO donors 3-morpholinosydnonimine hydrochloride (SIN-1) or z-1-[N-(3-ammoniopropyl)-N-(n-propyl) amino]diazen-1-ium-1,2-diolate (PAPA/NONOate) enhanced DA release with increasing stimulus frequency. This NO-mediated enhancement of frequency sensitivity of DA release was not prevented by inhibition of soluble guanylyl cyclase (sGC), DA transporters, or large conductance Ca2+-activated K+ channels, and did not require glutamatergic or GABAergic input. However, experiments to identify whether frequency-dependent NO effects were mediated via changes in powerful acetylcholine-DA interactions revealed multiple components to NO modulation of DA release. In the presence of a nicotinic receptor antagonist (dihydro-beta-erythroidine), NO donors increased DA release in a frequency-independent manner. These data suggest that NO in the NAc can modulate DA release through multiple GC-independent neuronal mechanisms whose net outcome varies depending on the activity in DA neurons and accumbal cholinergic interneurons. In the presence of accumbal acetylcholine, NO promotes the sensitivity of DA release to presynaptic activation, but with reduced acetylcholine input, NO will promote DA release in an activity-independent manner through a direct action on dopaminergic terminals. Neuropsychopharmacology (2011) 36, 1811-1822; doi:10.1038/npp.2011.62; published online 20 April 2011
引用
收藏
页码:1811 / 1822
页数:12
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