A Metal-Free Visible-Light Photoredox Construction and Direct C-H Functionalization of Pyridines: Green Synthesis of Polysubstituted Picolinaldehydes

被引：16

作者：

Zhang, Qun-Liang ^{[1
,2
]}

Yu, Qin-Qin ^{[1
]}

Ma, Li ^{[1
]}

Lu, Xuelian ^{[2
]}

Fan, Qing-Tian ^{[1
]}

Duan, Tian-Shun ^{[1
]}

Zhou, Yirong ^{[3
]}

Zhang, Fang-Lin ^{[1
,2
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China

[2] Wuhan Univ Technol, Shenzhen Res Inst, Shenzhen 518057, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 23期

基金：

中国国家自然科学基金;

关键词：

CATALYSIS; BONDS;

D O I：

10.1021/acs.joc.1c02312

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of a novel environmental benign and sustainable synthetic method for highly efficient construction and direct C-H functionalization of N-heterocycles remains a pivotal central research topic for organic and medicinal chemistry. Herein, a novel visible-light-enabled biomimetic aza-6 pi- electro-cyclization for efficient assembly of diverse pyridines and further tandem Minisci-type reaction were developed. A broad spectrum of polysubstituted picolinaldehydes were readily constructed with high efficacy and good functional group tolerance under metal- and oxidant-free conditions.

引用

页码：17244 / 17248

页数：5

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