Systematic review of tumour budding and association with common mutations in patients with colorectal cancer

被引：10

作者：

Hatthakarnkul, Phimmada ^{[1
]}

Quinn, Jean A. ^{[1
]}

Matly, Amna Ahmed Mohemmd ^{[1
]}

Ammar, Aula ^{[1
]}

van Wyk, Hester C. ^{[2
]}

McMillan, Donald C. ^{[2
]}

Edwards, Joanne ^{[1
]}

机构：

[1] Univ Glasgow, Wolfson Wohl Canc Res Ctr, Inst Canc Sci, Garscube Estate, Glasgow G61 1QH, Lanark, Scotland

[2] Univ Glasgow, Glasgow Royal Infirm, Sch Med, Glasgow G31 2ER, Lanark, Scotland

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2021年 / 167卷

关键词：

Tumour budding; KRAF/BRAF mutation; MSS/pMMR tumour; Systematic review; Colorectal cancer; MICROSATELLITE INSTABILITY; PROTEIN EXPRESSION; BRAF MUTATIONS; KRAS-MUTATION; SURVIVAL; STAGE; IMPACT; PROGRESSION; CARCINOMA; ONCOGENES;

D O I：

10.1016/j.critrevonc.2021.103490

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Despite a well-known prognostic role in colorectal cancer, the genomic profiling of tumour budding remains to be elucidated. We aim to review the association of common mutations with tumour budding. Methods: A systematic review of studies relating to tumour budding and genetic mutation in CRC was performed. The relationship between mutational status and tumour budding was evaluated using meta-analysis. Results: A total of 6153 patients from 17 articles were included. According to the meta-analysis, high-grade tumour budding was significantly associated with KRAS mutation (OR = 1.52, 95 %CI: 1.13-2.02, P = 0.005) and MSS/pMMR (OR = 2.06, 95 %CI: 1.42-2.97, P = 0.0001). Conclusion: The significant association between high-grade tumour budding and mutated KRAS or MSS/pMMR may suggest a role of these mutations in the development of the tumour budding phenotype and be useful for stratifying patient outcome in CRC.

引用

页数：7

共 54 条

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