Microdialysis as a way to measure antibiotics concentration in tissues

被引：39

作者：

Marchand, Sandrine ^{[1
,2
,3
]}

Chauzy, Alexia ^{[1
,2
]}

Dahyot-Fizelier, Claire ^{[1
,2
,4
]}

Couet, William ^{[1
,2
,3
]}

机构：

[1] Inserm U1070, Pole Biol Sante, Rue Georges Bonnet,TSA 51106, F-86073 Poitiers 9, France

[2] Univ Poitiers, UFR Med Pharm, 6 Rue Miletrie,TSA 51115, F-86073 Poitiers, France

[3] CHU Poitiers, Serv Toxicol Pharmacocinet, 2 Rue Miletrie,CS 90577, F-86021 Poitiers, France

[4] CHU Poitiers, Dept Anesthesie Reanimat, 2 Rue Miletrie,CS 90577, F-86021 Poitiers, France

来源：

PHARMACOLOGICAL RESEARCH | 2016年 / 111卷

关键词：

Microdialysis; Distribution; Tissue; Antibiotics; Pharmacokinetics; Pharmacodynamics; IN-VIVO MICRODIALYSIS; CENTRAL-NERVOUS-SYSTEM; ACUTE BRAIN-INJURY; DRUG DISTRIBUTION; PROTEIN-BINDING; BLISTER FLUID; PHARMACOLOGICAL-ACTIVITY; CLINICAL MICRODIALYSIS; IMIPENEM DISTRIBUTION; EXTRACELLULAR FLUIDS;

D O I：

10.1016/j.phrs.2016.06.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

As for all other drugs, antibiotics must reach their pharmacodynamic target in order to exert their effect, but because infection may occur in various tissues the distribution of antibiotics has always been of particular concern. In this article, we will first critically review the various methodologies available to study antibiotics tissue distribution, including microdialysis, secondly we will show how basic pharmacokinetic concepts may help to predict or interpret antibiotics tissue distribution and third we will address the question of linking antibiotics tissue distribution with their antimicrobial effect, using modern pharmacokinetic-pharmacodynamic methods. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：201 / 207

页数：7

共 59 条

[1] Pharmacokinetic and Pharmacodynamic Parameters of Antimicrobials Potential for Providing Dosing Regimens that Are Less Vulnerable to Resistance [J].