Excess mortality from mental, neurological and substance use disorders in the Global Burden of Disease Study 2010

被引:100
作者
Charlson, F. J. [1 ,2 ,3 ]
Baxter, A. J. [1 ,2 ,3 ]
Dua, T. [4 ]
Degenhardt, L. [3 ,5 ,6 ]
Whiteford, H. A. [1 ,2 ,3 ]
Vos, T. [3 ]
机构
[1] Queensland Ctr Mental Hlth Res, Wacol, Qld, Australia
[2] Univ Queensland, Sch Populat Hlth, Herston, Qld, Australia
[3] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA
[4] WHO, Dept Mental Hlth & Substance Abuse, Geneva, Switzerland
[5] Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
[6] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic 3010, Australia
关键词
Global burden of disease; mental health; mortality; neuropsychiatry; AUTISM SPECTRUM DISORDERS; ILLICIT DRUG-USE; SYSTEMATIC ANALYSIS; RISK-FACTOR; FOLLOW-UP; SUBSTITUTION THERAPY; PREMATURE MORTALITY; CONVULSIVE EPILEPSY; LIFE EXPECTANCY; INJECT DRUGS;
D O I
10.1017/S2045796014000687
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Aims. Mortality-associated burden of disease estimates from the Global Burden of Disease 2010 (GBD 2010) may erroneously lead to the interpretation that premature death in people with mental, neurological and substance use disorders (MNSDs) is inconsequential when evidence shows that people with MNSDs experience a significant reduction in life expectancy. We explore differences between cause-specific and excess mortality of MNSDs estimated by GBD 2010. Methods. GBD 2010 cause-specific death estimates were produced using the International Classification of Diseases death-coding system. Excess mortality (all-cause) was estimated using natural history models. Additional mortality attributed to MNSDs as underlying causes but not captured through GBD 2010 methodology is quantified in the comparative risk assessments. Results. In GBD 2010, MNSDs were estimated to be directly responsible for 840 000 deaths compared with more than 13 million excess deaths using natural history models. Conclusions. Numbers of excess deaths and attributable deaths clearly demonstrate the high degree of mortality associated with these disorders. There is substantial evidence pointing to potential causal pathways for this premature mortality with evidence-based interventions available to address this mortality. The life expectancy gap between persons with MNSDs and the general population is high and should be a focus for health systems reform.
引用
收藏
页码:121 / 140
页数:20
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