Effects of alcohol and cigarette smoking on change in serum estrone levels in postmenopausal women randomly assigned to fixed doses of conjugated equine estrogens with or without a progestin

被引：8

作者：

McDivit, Anna M. ^{[2
]}

Greendale, Gail A. ^{[1
]}

Stanczyk, Frank Z. ^{[3
]}

Huang, Mei-Hua ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Div Geriatr, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] Cleveland Clin, Cleveland, OH 44106 USA

[3] Univ So Calif, Dept Obstet & Gynaecol Prevent Med, California Keck Sch Med, Los Angeles, CA USA

来源：

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2008年 / 15卷 / 02期

关键词：

menopause; hormone therapy; serum estrone; alcohol; smoking;

D O I：

10.1097/gme.0b013e3181407cb2

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine the effects of alcohol and smoking on serum estrone levels among women assigned to hormone therapy. Design: We analyzed the data from 676 participants in the Postmenopausal Estrogen/Progestin Interventions study. Results: Those who consumed more than 5.5 g of alcohol daily demonstrated greater rises in serum estrone than those who drank less (> 0 to <= 55.5 g/d) (P = 0.07) and those who were abstinent (P = 0.09). Current smokers had lesser gains in serum estrone compared with former smokers (P < 0.0001) and never smokers (P < 0.0001). Conclusions: Alcohol consumption augmented and smoking diminished serum estrone levels achieved while women were taking hormone therapy.

引用

页码：382 / 385

页数：4