Food Allergy and Atopic Dermatitis: How Are They Connected?

被引:41
作者
Heratizadeh, Annice [1 ]
Wichmann, Katja [2 ]
Werfel, Thomas [2 ]
机构
[1] Hannover Med Sch, Div Immunodermatol & Allergy Res, Dept Dermatol & Allergy, D-30449 Hannover, Germany
[2] Hannover Med Sch, Div Immunodermatol & Allergy Res, Dept Dermatol & Allergy, D-30625 Hannover, Germany
关键词
Allergens; Atopic dermatitis; Food allergy; Sensitization; Pathogenesis; Prevention; Prevalence; PLACEBO-CONTROLLED TRIAL; 1ST; 6; MONTHS; PRIMARY PREVENTION; DOUBLE-BLIND; BIRCH POLLEN; ECZEMATOUS REACTIONS; BIRTH COHORT; CHILDREN; SENSITIZATION; RISK;
D O I
10.1007/s11882-011-0202-y
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Food allergy predominantly affects children rather than adults with atopic dermatitis (AD). Early food sensitization has been found to be significantly associated with AD. Three different patterns of clinical reactions to food allergens in AD patients have been identified: 1) immediate-type symptoms, 2) isolated eczematous late-type reactions, and 3) combined reactions. Whereas in children, allergens from cow's milk, hen's egg, soy, wheat, fish, peanut, or tree nuts are primarily responsible for allergic reactions, birch pollen-related food allergens seem to play a major role in adolescent and adults with AD in Central and Northern Europe. Defects in the epidermal barrier function seem to facilitate the development of sensitization to allergens following epicutaneous exposure. The relevance of defects in the gut barrier as well as genetic characteristics associated with an increased risk of food allergy remain to be further investigated. Many studies focus on sufficient strategies of prevention, which actually include breastfeeding or feeding with hydrolyzed formula during the first 4 months of life.
引用
收藏
页码:284 / 291
页数:8
相关论文
共 63 条
  • [41] Factors associated with the development of peanut allergy in childhood
    Lack, G
    Fox, D
    Northstone, K
    Golding, J
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (11) : 977 - 985
  • [42] Food allergy
    Lack, Gideon
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (12) : 1252 - 1260
  • [43] Murine model of atopic dermatitis associated with food hypersensitivity
    Li, XM
    Kleiner, G
    Huang, CK
    Lee, SY
    Schofield, B
    Soter, NA
    Sampson, HA
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (04) : 693 - 702
  • [44] Blackcurrant seed oil for prevention of atopic dermatitis in newborns: a randomized, double-blind, placebo-controlled trial
    Linnamaa, P.
    Savolainen, J.
    Koulu, L.
    Tuomasjukka, S.
    Kallio, H.
    Yang, B.
    Vahlberg, T.
    Tahvonen, R.
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2010, 40 (08) : 1247 - 1255
  • [45] Utility of the ratio of food-specific IgE/total IgE in predicting symptomatic food allergy in children
    Mehl, A
    Verstege, A
    Staden, U
    Kulig, M
    Nocon, M
    Beyer, K
    Niggemann, B
    [J]. ALLERGY, 2005, 60 (08) : 1034 - 1039
  • [46] Soybean allergy in patients allergic to birch pollen:: Clinical investigation and molecular characterization of allergens
    Mittag, D
    Vieths, S
    Vogel, L
    Becker, WM
    Rihs, HP
    Helbling, A
    Wüthrich, B
    Ballmer-Weber, BK
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (01) : 148 - 154
  • [47] A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age
    Moro, G.
    Arslanoglu, S.
    Stahl, B.
    Jelinek, J.
    Wahn, U.
    Boehm, G.
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 2006, 91 (10) : 814 - 819
  • [48] Allergy prevention
    Muche-Borowski, Cathleen
    Kopp, Matthias
    Reese, Imke
    Sitter, Helmut
    Werfel, Thomas
    Scaefer, Torsten
    [J]. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2010, 8 (09): : 718 - 724
  • [49] Hazelnut allergy:: A double-blind, placebo-controlled food challenge multicenter study
    Ortolani, C
    Ballmer-Weber, BK
    Hansen, KS
    Ispano, M
    Wüthrich, B
    Bindslev-Jensen, C
    Ansaloni, R
    Vannucci, L
    Pravettoni, V
    Scibilia, J
    Poulsen, LK
    Pastorello, EA
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 105 (03) : 577 - 581
  • [50] Birch pollen-related foods trigger atopic dermatitis in patients with specific cutaneous T-cell responses to birch pollen antigens
    Reekers, R
    Busche, M
    Wittmann, M
    Kapp, A
    Werfel, T
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 104 (02) : 466 - 472