Food Allergy and Atopic Dermatitis: How Are They Connected?

被引:41
作者
Heratizadeh, Annice [1 ]
Wichmann, Katja [2 ]
Werfel, Thomas [2 ]
机构
[1] Hannover Med Sch, Div Immunodermatol & Allergy Res, Dept Dermatol & Allergy, D-30449 Hannover, Germany
[2] Hannover Med Sch, Div Immunodermatol & Allergy Res, Dept Dermatol & Allergy, D-30625 Hannover, Germany
关键词
Allergens; Atopic dermatitis; Food allergy; Sensitization; Pathogenesis; Prevention; Prevalence; PLACEBO-CONTROLLED TRIAL; 1ST; 6; MONTHS; PRIMARY PREVENTION; DOUBLE-BLIND; BIRCH POLLEN; ECZEMATOUS REACTIONS; BIRTH COHORT; CHILDREN; SENSITIZATION; RISK;
D O I
10.1007/s11882-011-0202-y
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Food allergy predominantly affects children rather than adults with atopic dermatitis (AD). Early food sensitization has been found to be significantly associated with AD. Three different patterns of clinical reactions to food allergens in AD patients have been identified: 1) immediate-type symptoms, 2) isolated eczematous late-type reactions, and 3) combined reactions. Whereas in children, allergens from cow's milk, hen's egg, soy, wheat, fish, peanut, or tree nuts are primarily responsible for allergic reactions, birch pollen-related food allergens seem to play a major role in adolescent and adults with AD in Central and Northern Europe. Defects in the epidermal barrier function seem to facilitate the development of sensitization to allergens following epicutaneous exposure. The relevance of defects in the gut barrier as well as genetic characteristics associated with an increased risk of food allergy remain to be further investigated. Many studies focus on sufficient strategies of prevention, which actually include breastfeeding or feeding with hydrolyzed formula during the first 4 months of life.
引用
收藏
页码:284 / 291
页数:8
相关论文
共 63 条
  • [1] MILK-INDUCED ECZEMA IS ASSOCIATED WITH THE EXPANSION OF T-CELLS EXPRESSING CUTANEOUS LYMPHOCYTE ANTIGEN
    ABERNATHYCARVER, KJ
    SAMPSON, HA
    PICKER, LJ
    LEUNG, DYM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (02) : 913 - 918
  • [2] Gut microbiota and development of atopic eczema in 3 European birth cohorts
    Adlerberth, Ingegerd
    Strachan, David P.
    Matricardi, Paolo M.
    Ahrne, Siv
    Orfei, Lia
    Aberg, Nils
    Perkin, Michael R.
    Tripodi, Salvatore
    Hesselmar, Bill
    Saalman, Robert
    Coates, Anthony R.
    Bonanno, Carmen L.
    Panetta, Valentina
    Wold, Agnes E.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (02) : 343 - 350
  • [3] Partially Hydrolyzed 100% Whey Protein Infant Formula and Reduced Risk of Atopic Dermatitis: A Meta-analysis
    Alexander, Dominik D.
    Cabana, Michael D.
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2010, 50 (04) : 422 - 430
  • [4] Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis
    Anandan, C.
    Nurmatov, U.
    Sheikh, A.
    [J]. ALLERGY, 2009, 64 (06) : 840 - 848
  • [5] Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life
    Arslanoglu, Sertac
    Moro, Guido E.
    Schmitt, Joachim
    Tandoi, Laura
    Rizzardi, Silvia
    Boehm, Gunther
    [J]. JOURNAL OF NUTRITION, 2008, 138 (06) : 1091 - 1095
  • [6] Reported symptoms to peanut between 4 and 8 years among children sensitized to peanut and birch pollen - results from the BAMSE birth cohort
    Asarnoj, A.
    Ostblom, E.
    Ahlstedt, S.
    Hedlin, G.
    Lilja, G.
    van Hage, M.
    Wickman, M.
    [J]. ALLERGY, 2010, 65 (02) : 213 - 219
  • [7] Carrot allergy:: Double-blinded, placebo-controlled food challenge and identification of allergens
    Ballmer-Weber, BK
    Wüthrich, B
    Wangorsch, A
    Fötisch, K
    Altmann, F
    Vieths, S
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (02) : 301 - 307
  • [8] Celery allergy confirmed by double-blind, placebo-controlled food challenge:: A clinical study in 32 subjects with a history of adverse reactions to celery root
    Ballmer-Weber, BK
    Vieths, S
    Lüttkopf, D
    Heuschmann, P
    Wüthrich, B
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (02) : 373 - 378
  • [9] Component-resolved diagnosis with recombinant allergens in patients with cherry allergy
    Ballmer-Weber, BK
    Scheurer, S
    Fritsche, P
    Enrique, E
    Cistero-Bahima, A
    Haase, T
    Wüthrich, B
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 110 (01) : 167 - 173
  • [10] An update on the genetics of atopic dermatitis: Scratching the surface in 2009
    Barnes, Kathleen C.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (01) : 16 - 29