A novel method for the synthesis of 2,2-diaryl-1,1-difluoroethenes

被引：24

作者：

Choi, Ji Hoon ^{[1
]}

Jeong, In Howa ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Wonju 220710, South Korea

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 06期

关键词：

D O I：

10.1016/j.tetlet.2007.12.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta,beta-Difluoro-alpha-phenylvinylstannane 3 was prepared in 60% yield from the reaction of P,beta-difluoro-alpha-phenylvinylsulfone 2 with tributyltin hydride in refluxing benzene for 5 h. The cross-coupling reaction of 3 with aryl iodides bearing substituents such as proton, fluoro, chloro, bromo, methoxy, methyl, trifluoromethyl, and nitro on ortho, meta, para positions of the benzene ring in the presence of 10 mol % Pd(PPh(3))(4)/10 mol % CuI afforded the corresponding 2,2-diaryl-1,1-difluoroethenes 4 in 22-82% yields. (c) 2007 Elsevier Ltd. All rights reserved.

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页码：952 / 955

页数：4

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