TRAPping telomerase within the intestinal stem cell niche

被引：6
|
作者：
Pech, Matthew F. [1 ,2 ]
Artandi, Steven E. [1 ,2 ]
机构：
[1] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Canc Biol Program, Stanford, CA 94305 USA
来源：
EMBO JOURNAL | 2011年 / 30卷 / 06期
关键词：
IDENTIFICATION;
D O I：
10.1038/emboj.2011.51
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adult intestinal stem cells (ISCs) reside at the crypt base, where they continuously proliferate to maintain homeostasis of the intestinal epithelium. As a result of a lifetime of cell division, these LGR5 + ISCs face the combined risk of genomic mutations and telomere attrition. In this issue of EMBOJ, Schepers et al (2011) examine whether ISCs employ telomerase expression and asymmetric chromosome segregation to protect their genome.
引用
收藏
页码：986 / 987
页数：2
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