COMPOSITE BIODEGRADABLE POLYMERIC MATRIX DOPED WITH HALLOYSITE NANOTUBES FOR THE REPAIR OF BONE DEFECTS IN DOGS

被引：12
作者：
Naumenko, Ekaterina [1 ]
Zakirova, Elena [1 ]
Guryanov, Ivan [1 ]
Akhatova, Farida [1 ]
Sergeev, Mikhail [2 ]
Valeeva, Anastasia [2 ]
Fakhrullin, Rawil [1 ]
机构：
[1] Kazan Fed Univ, Inst Fundamental Med & Biol, Kreml Uram 18, Kazan 420008, Republic Of Tat, Russia
[2] Kazan State Acad Vet Med, Siberian Tract 35, Kazan 420074, Republic Of Tat, Russia
来源：
CLAYS AND CLAY MINERALS | 2021年 / 69卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
Adipose-derived mesenchymal stem cells; Biopolymeric scaffolds; Bone restoration; Halloysite nanotubes; Osteoconductive properties; MESENCHYMAL STEM-CELLS; CLAY NANOTUBES; BIOMEDICAL APPLICATIONS; CAENORHABDITIS-ELEGANS; AUTOGENOUS BONE; FIXATION; SUBSTITUTES; EPICUTICLE; SCAFFOLDS; CHITOSAN;
D O I：
10.1007/s42860-021-00152-7
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The use, in veterinary practice, of a three-dimensional biopolymer matrix (based on chitosan, agarose, and gelatin and doped with halloysite nanotubes) as a vehicle for mesenchymal stem cells (MSCs) to repair bone defects is reported here. The nanocomposite, combined with allogenic adipose-derived stem cells, was suitable for the repair of bone defects in dogs when paired with standard surgery involving metal Kirshner wires. The absence of inflammatory reactions to biopolymer matrices with allogenic stem cells was revealed in the case of an animal prone to inflammatory and allergic reactions. In addition, positive dynamics in the fusion of chronic bone defects without rejection reactions was observed after using a biopolymer matrix with MSCs.
引用
收藏
页码：522 / 532
页数：11
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