Integrating plant molecular farming and materials research for next-generation vaccines

被引:94
作者
Chung, Young Hun [1 ]
Church, Derek [2 ]
Koellhoffer, Edward C. [3 ]
Osota, Elizabeth [2 ,4 ]
Shukla, Sourabh [2 ]
Rybicki, Edward P. [5 ]
Pokorski, Jonathan K. [2 ,6 ,7 ]
Steinmetz, Nicole F. [1 ,2 ,3 ,6 ,7 ,8 ]
机构
[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Biomed Sci Program, La Jolla, CA 92093 USA
[5] Univ Cape Town, Dept Mol & Cell Biol, Cape Town, South Africa
[6] Univ Calif San Diego, Inst Mat Discovery & Design, La Jolla, CA 92093 USA
[7] Univ Calif San Diego, Ctr Nanoimmuno Engn, La Jolla, CA 92093 USA
[8] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
基金
英国医学研究理事会; 新加坡国家研究基金会;
关键词
NATIONAL IMMUNIZATION CAMPAIGN; CONTROLLED DRUG-DELIVERY; MIDDLE-INCOME COUNTRIES; ORAL POLIO VACCINE; CELL CULTURE; COLD-CHAIN; BIOMEDICAL APPLICATIONS; THERMOSTABLE VACCINES; RECOMBINANT PROTEINS; POLYMER MICRONEEDLES;
D O I
10.1038/s41578-021-00399-5
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Biologics - medications derived from a biological source - are increasingly used as pharmaceuticals, for example, as vaccines. Biologics are usually produced in bacterial, mammalian or insect cells. Alternatively, plant molecular farming, that is, the manufacture of biologics in plant cells, transgenic plants and algae, offers a cheaper and easily adaptable strategy for the production of biologics, in particular, in low-resource settings. In this Review, we discuss current vaccination challenges, such as cold chain requirements, and highlight how plant molecular farming in combination with advanced materials can be applied to address these challenges. The production of plant viruses and virus-based nanotechnologies in plants enables low-cost and regional fabrication of thermostable vaccines. We also highlight key new vaccine delivery technologies, including microneedle patches and material platforms for intranasal and oral delivery. Finally, we provide an outlook of future possibilities for plant molecular farming of next-generation vaccines and biologics. Cold chain requirements, distribution challenges and high costs limit the global rollout of many vaccines. This Review discusses plant molecular farming in combination with advanced materials strategies as a new platform for the local production of thermostable vaccines and other biologics.
引用
收藏
页码:372 / 388
页数:17
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