SARS-CoV-2 viral RNA levels are not 'viral load'

被引：19

作者：

Michalakis, Yannis ^{[1
,2
]}

Sofonea, Mircea T. ^{[1
,2
]}

Alizon, Samuel ^{[1
]}

Bravo, Ignacio G. ^{[1
,2
]}

机构：

[1] Univ Montpellier, CNRS, IRD, MIVEGEC, Montpellier, France

[2] Ctr Res Ecol & Evolut Dis CREES, Montpellier, France

来源：

TRENDS IN MICROBIOLOGY | 2021年 / 29卷 / 11期

关键词：

D O I：

10.1016/j.tim.2021.08.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ct values are commonly used as proxies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 'viral load'. Since coronaviruses are positive single-stranded RNA [(+)ssRNA] viruses, current reverse transcription (RT)-qPCR target amplification does not distinguish replicative from transcriptional RNA. Although analyses of Ct values remain informative, equating them with viral load may lead to flawed conclusions as it is presently unknown whether (and to what extent) variation in Ct reflects variation in viral load or in gene expression.

引用

页码：970 / 972

页数：3

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