Inhibitory effect of exendin-4 on secretory group IIA phospholipase A2

被引：3

作者：

Lee, Wonhwa ^{[1
,2
]}

Kwak, Soyoung ^{[1
]}

Lee, Hyun-Shik ^{[3
]}

Na, Dong Hee ^{[1
]}

Lee, You-Mie ^{[1
]}

Bae, Jong-Sup ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Pharmaceut Sci Res Inst, CMRI, Coll Pharm, Taegu 702701, South Korea

[2] Kyungpook Natl Univ, Sch Med, Plus KNU Biomed Convergence Program BK21, Dept Biochem & Cell Biol, Taegu 702701, South Korea

[3] Kyungpook Natl Univ, Plus KNU Creat BioRes Grp BK21, Sch Life Sci, ABRC,CMRI, Taegu 702701, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 459卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Exendin-4; HUVEC; sPLA2-IIA; Inflammation; GLUCAGON-LIKE PEPTIDE-1; IN-VITRO; ANTITHROMBOTIC ACTIVITIES; ANTIINFLAMMATORY ACTION; SELECTIVE INHIBITOR; EXPERIMENTAL SEPSIS; ENDOTHELIAL-CELLS; GENE-EXPRESSION; HEPATOMA-CELLS; GLP-1; RECEPTOR;

D O I：

10.1016/j.bbrc.2015.02.165

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exendin-4 (EX4), a glucagon-like peptide-1 receptor agonist, has been reported to attenuate myocardial ischemia and reperfusion injury and inflammatory or oxidative responses. The expression level of secretory group IIA phospholipase A2 (sPLA2-IIA) is elevated in inflammatory diseases. Lipopolysaccharide (LPS) upregulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Here, EX4 was examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mice. Pre-treatment of cells or mice with EX4 inhibited LPS-induced sPLA2-IIA expression and activity. Additionally, EX4 suppressed LPS-induced activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2. Therefore, these results show that EX4 inhibited LPS-induced expression of sPLA2-IIA by suppressing cPLA2 and ERK 1/2. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：650 / 654

页数：5

共 52 条

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