Endocrine-disrupting chemicals and behaviour: A high risk to take?

被引：15

作者：

Bakoyiannis, Ioannis ^{[1
,3
]}

Kitraki, Efthymia ^{[2
]}

Stamatakis, Antonios ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Fac Nursing, Biol Biochem Lab, Athens, Greece

[2] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Basic Sci Lab, Fac Dent, Athens, Greece

[3] Univ Bordeaux, INRAE, Bordeaux INP, NutriNeuro,UMR 1286, F-33077 Bordeaux, France

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2021年 / 35卷 / 05期

关键词：

endocrine disruptors; BPA; phthalate; anxiety; social behavior; memory; ANXIETY-LIKE BEHAVIOR; DEPRESSION-LIKE BEHAVIORS; BISPHENOL-A EXPOSURE; PERINATAL EXPOSURE; SEXUAL-DIFFERENTIATION; DI-(2-ETHYLHEXYL) PHTHALATE; DEVELOPMENTAL EXPOSURE; LACTATIONAL EXPOSURE; GESTATIONAL EXPOSURE; MATERNAL EXPOSURE;

D O I：

10.1016/j.beem.2021.101517

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Early life exposure to endocrine-disrupting chemicals (EDCs) is considered a potential risk factor for aberrant brain development and the emergence of behavioral deficits. The purpose of this review is to summarize the toxic effects of bisphenol-A (BPA) and phthalate exposure during pre-, -post-or perinatal life on different types of behaviour in male and female rodents. Despite results not being always consistent, most probably due to methodological issues, it is highly probable that early life exposure to BPA or/and phthalates, affects various aspects of behaviour in the offspring. Adverse effects include: Increased levels of anxiety, altered exploratory behaviour, reduced social interaction or increased aggression and deficits in spatial or recognition learning and memory. These effects have been observed with a wide range of doses, in some cases even below the currently employed Tolerable Daily Intake dose for either BPA or phthalates. (c) 2021 Elsevier Ltd. All rights reserved.

引用

页数：12

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