Omics Integration for Mitochondria Systems Biology

被引：23

作者：

Hu, Xin ^{[1
]}

Go, Young-Mi ^{[1
]}

Jones, Dean P. ^{[1
]}

机构：

[1] Emory Univ, Dept Med, Div Pulm Allergy & Crit Care Med, 615 Michael St,205P Whitehead Biomed Res Bldg, Atlanta, GA 30322 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2020年 / 32卷 / 12期

关键词：

mitochondria; omics; systems biology; biological network; integration; ELECTRON-TRANSPORT CHAIN; SKELETAL-MUSCLE; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; IRON HOMEOSTASIS; CELL-METABOLISM; MODEL ORGANISM; ACID SYNTHESIS; CANCER; YEAST;

D O I：

10.1089/ars.2019.8006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent Advances: Many recent advances have been facilitated by the development of new omics tools, which create opportunities to use data-driven analysis of omics data to address these complex adaptive and maladaptive mechanisms of mitochondrial reprogramming in human disease. Critical Issues: Application of omics integration to model systems reveals a critical role for metal ion homeostasis broadly impacting mitochondrial reprogramming. Importantly, data show that trans-omics associations are more robust and biologically relevant than single omics associations. Future Directions: Application of omics integration to mitophagy research creates new opportunities to link the complex, interactive functions of mitochondrial form and function in mitochondria systems biology. Antioxid. Redox Signal. 00, 000-000.

引用

页码：853 / 872

页数：20

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