Cobalamin's (Vitamin B12) Surprising Function as a Photoreceptor

被引:28
作者
Cheng, Zhuo [1 ]
Yamamoto, Haruki [1 ]
Bauer, Carl E. [1 ]
机构
[1] Indiana Univ, Mol & Cellular Biochem Dept, Bloomington, IN 47405 USA
关键词
D O I
10.1016/j.tibs.2016.05.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cobalamin (Vitamin B-12) is an adenosylor methyl-donating cofactor for many enzymes, yet many proteins with unknown or nonenzymatic function also contain B-12-binding domains. Recent studies show that light excitation energy can promote covalent linkage of B-12 to transcription factors with this linkage, affecting gene expression. Thus, B-12 now has a newly described regulatory function. Here, our bioinformatics analysis reveals other transcription factors, photoreceptors, kinases, and oxygen sensors that harbor a B-12-binding domain that could also regulate activity in response to light absorption.
引用
收藏
页码:647 / 650
页数:4
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