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Site-specific halloysite functionalization by polydopamine: A new synthetic route for potential near infrared-activated delivery system
被引:21
作者:
Alfieri, Maria Laura
[1
]
Massaro, Marina
[2
]
D'Ischia, Marco
[1
]
D'Errico, Gerardino
[1
]
Gallucci, Noemi
[1
]
Gruttadauria, Michelangelo
[2
]
Licciardi, Mariano
[3
]
Liotta, Leonarda F.
[4
]
Nicotra, Giuseppe
[5
]
Sfuncia, Gianfranco
[5
]
Riela, Serena
[2
]
机构:
[1] Univ Napoli Federico II, Dipartimento Sci Chim, Via Cinthia 4, I-80126 Naples, Italy
[2] Univ Palermo, Sez Chim, Dipartimento Sci & Tecnol Biol Chim & Farmaceut S, Viale Sci,Ed 17, I-90128 Palermo, Italy
[3] Univ Palermo, Sez Chim & Tecnol Farmaceut, Dipartimento Sci & Tecnol Biol Chim & Farmaceut S, Via Archirafi 32, I-90123 Palermo, Italy
[4] Ist Studio Mat Nanostrutturati ISMN CNR, Via Ugo La Malfa 153, I-90146 Palermo, Italy
[5] CNR IMM, Zona Ind Str 8, I-95121 Catania, Italy
关键词:
Halloysite nanotubes;
Site-specific functionalization;
Polydopamine;
Secondary modification;
Biotin-avidin interaction;
Delivery system;
Hyperthermia effects;
SELECTIVE MODIFICATION;
OXIDATIVE-DEGRADATION;
NANOTUBES;
DOPAMINE;
MEMBRANES;
HYBRID;
NANOPARTICLES;
EUMELANIN;
DESIGN;
AGENT;
D O I:
10.1016/j.jcis.2021.08.155
中图分类号:
O64 [物理化学(理论化学)、化学物理学];
学科分类号:
070304 ;
081704 ;
摘要:
Halloysite nanotubes (HNTs) represent a versatile core structure for the design of functional nanosystems of biomedical interest. However, the development of selective methodologies for the site-controlled functionalization of the nanotubes at specific sites is not an easy task. This study aims to accomplish a procedure for the site-selective/specific, "pin-point", functionalization of HNTs with polydopamine (HNTs@PDA). This goal was achieved, at pH 6.5, by exploiting the basicity of ZnO nanoparticles anchored on the HNTs external surface (HNTs@ZnO) to induce a punctual polydopamine polymerization and coating. The morphology and the chemical composition of the nanomaterial was demonstrated by several techniques. Turbidimetric analysis showed that PDA coating affected the aqueous stability of HNTs@PDA compared to both HNTs@ZnO and HNTs. Notably, hyperthermia studies revealed that the nanomaterial induced a local thermic rise, up to 50 degrees C, under near-infrared (NIR) irradiation. Furthermore, secondary functionalization of HNTs@PDA by selective grafting of biotin onto the PDA coating followed by avidin binding was also accomplished. (c) 2021 Elsevier Inc. All rights reserved.
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页码:1779 / 1791
页数:13
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