Cereblon in health and disease

被引：38

作者：

Kim, Hyoung Kyu ^{[1
,2
]}

Ko, Tae Hee ^{[1
]}

Nyamaa, Bayalagmaa ^{[1
]}

Lee, Sung Ryul ^{[1
,2
]}

Kim, Nari ^{[1
]}

Ko, Kyung Soo ^{[1
]}

Rhee, Byoung Doo ^{[1
]}

Park, Chul-Seung ^{[3
,4
]}

Nilius, Bernd ^{[5
]}

Han, Jin ^{[1
]}

机构：

[1] Inje Univ, Natl Res Lab Mitochondrial Signaling, Cardiovasc & Metab Dis Ctr, Dept Physiol,Dept Hlth Sci & Technol,Coll Med,Plu, Bokji Ro 75, Busan 47392, South Korea

[2] Inje Univ, Dept Integrated Biomed Sci, Coll Med, Busan, South Korea

[3] Gwangju Inst Sci & Technol, Sch Life Sci, Gwangju 500712, South Korea

[4] Gwangju Inst Sci & Technol, Natl Leading Res Lab Ion Channels, Gwangju 500712, South Korea

[5] Katholieke Univ Leuven, Lab Ion Channel Res, Dept Cellular & Mol Med, Leuven, Belgium

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2016年 / 468卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Cereblon; Mental retardation; BKCa; E3 ligase complex; AMPK; Immunomodulatory drugs; CHRONIC LYMPHOCYTIC-LEUKEMIA; E3 UBIQUITIN LIGASE; IDIOPATHIC GENERALIZED EPILEPSY; ENDOPLASMIC-RETICULUM STRESS; MULTIPLE-MYELOMA CELLS; BK CHANNEL ACTIVITY; MENTAL-RETARDATION; THALIDOMIDE TERATOGENICITY; CONFORMATIONAL DEFECT; POTASSIUM CHANNEL;

D O I：

10.1007/s00424-016-1854-1

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that has been linked to autosomal recessive non-syndromic mental retardation. Several key findings suggest diverse roles of CRBN, including its regulation of the large-conductance calcium- and voltage-activated potassium (BKCa) channels, regulation of thalidomide-binding proteins, and mediation of lenalidomide treatment in multiple myeloma. Recent studies also indicate that CRBN is involved in energy metabolism and negatively regulates AMP-activated protein kinase signaling. Mice with genetic depletion of CRBN are resistant to various stress conditions including a high-fat diet, endoplasmic reticulum stress, ischemia/reperfusion injury, and alcohol-related liver damage. In this review, we discuss the various roles of CRBN in human health and disease and suggest avenues for further research to enhance our basic knowledge and clinical application of CRBN.

引用

页码：1299 / 1309

页数：11

共 83 条

[21] Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity [J].