Characterization and distribution of HLA-B*5002 in a Spanish population sample

被引：9

作者：

Balas, A ^{[1
]}

Santos, S ^{[1
]}

García-Sánchez, F ^{[1
]}

Lillo, R ^{[1
]}

Merino, L ^{[1
]}

Vicario, JL ^{[1
]}

机构：

[1] Reg Ctr Transfus Madrid, Madrid 28009, Spain

来源：

TISSUE ANTIGENS | 1998年 / 52卷 / 02期

关键词：

HLA polymorphism; HLA serology; HLA-B*5002; Spanish population;

D O I：

10.1111/j.1399-0039.1998.tb02283.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA-B45, in contrast to B44, does not show molecular polymorphism, We have found a group of Caucasian Spanish individuals, serologically typed as B45, showing an unexpected HLA-B12 PCR-SSO subtyping pattern. Complete coding region sequencing and B45 subtyping by PCR-SSO demonstrated that the B45 serologic specificity is constituted by two molecular alleles: B*4501 and B*5002. B*5002 is recognized by polyclonal and monoclonal allosera against B12 and B45, whereas it is not detected by B21, B49, or B50 reagents, providing a new example of poor correlation between serology and structure. B*5002 explains an important subset (18%) of the B45-positive individuals of the Spanish population studied, and almost half are included in a very infrequent haplotypic association, Cw6-B*5002-DRB1*0406-DQA1*03-DQB1*0402.

引用

页码：183 / 186

页数：4

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