Noncoding RNAs: Regulators of the Mammalian Transcription Machinery

被引：41
作者：
Eidem, Tess M. [1 ]
Kugel, Jennifer F. [1 ]
Goodrich, James A. [1 ]
机构：
[1] Univ Colorado, Dept Chem & Biochem, 596 UCB, Boulder, CO 80309 USA
来源：
JOURNAL OF MOLECULAR BIOLOGY | 2016年 / 428卷 / 12期
关键词：
RNA polymerase II; circular RNAs; enhancer RNAs; tethered RNAs; divergent RNAs; NEGATIVE ELONGATION-FACTOR; POLYMERASE-II; U1; SNRNP; DIVERGENT TRANSCRIPTION; CIRCULAR RNAS; ENHANCER RNAS; NASCENT RNA; P-TEFB; MEDIATOR; ROLES;
D O I：
10.1016/j.jmb.2016.02.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcription by RNA polymerase II (Pol II) is required to produce mRNAs and some noncoding RNAs (ncRNAs) within mammalian cells. This coordinated process is precisely regulated by multiple factors, including many recently discovered ncRNAs. In this perspective, we will discuss newly identified ncRNAs that facilitate DNA looping, regulate transcription factor binding, mediate promoter-proximal pausing of Pol II, and/or interact with Pol II to modulate transcription. Moreover, we will discuss new roles for ncRNAs, as well as a novel Pol II RNA-dependent RNA polymerase activity that regulates an ncRNA inhibitor of transcription. As the multifaceted nature of ncRNAs continues to be revealed, we believe that many more ncRNA species and functions will be discovered. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2652 / 2659
页数：8
相关论文
共 44 条
[31]   Circular RNA: A new star of noncoding RNAs [J].
Qu, Shibin ;
Yang, Xisheng ;
Li, Xiaolei ;
Wang, Jianlin ;
Gao, Yuan ;
Shang, Runze ;
Sun, Wei ;
Dou, Kefeng ;
Li, Haimin .
CANCER LETTERS, 2015, 365 (02) :141-148
[32]   NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding [J].
Rao, Jampani Nageswara ;
Schweimer, Kristian ;
Wenzel, Sabine ;
Woehrl, Birgitta M. ;
Roesch, Paul .
BIOCHEMISTRY, 2008, 47 (12) :3756-3761
[33]   Enhancer RNA Facilitates NELF Release from Immediate Early Genes [J].
Schaukowitch, Katie ;
Joo, Jae-Yeol ;
Liu, Xihui ;
Watts, Jonathan K. ;
Martinez, Carlos ;
Kim, Tae-Kyung .
MOLECULAR CELL, 2014, 56 (01) :29-42
[34]   Divergent Transcription from Active Promoters [J].
Seila, Amy C. ;
Calabrese, J. Mauro ;
Levine, Stuart S. ;
Yeo, Gene W. ;
Rahl, Peter B. ;
Flynn, Ryan A. ;
Young, Richard A. ;
Sharp, Phillip A. .
SCIENCE, 2008, 322 (5909) :1849-1851
[35]   Transcription factor trapping by RNA in gene regulatory elements [J].
Sigova, Alla A. ;
Abraham, Brian J. ;
Ji, Xiong ;
Molinie, Benoit ;
Hannett, Nancy M. ;
Guo, Yang Eric ;
Jangi, Mohini ;
Giallourakis, Cosmas C. ;
Sharp, Phillip A. ;
Young, Richard A. .
SCIENCE, 2015, 350 (6263) :978-981
[36]   Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells [J].
Sigova, Alla A. ;
Mullen, Alan C. ;
Molinie, Benoit ;
Gupta, Sumeet ;
Orlando, David A. ;
Guenther, Matthew G. ;
Almada, Albert E. ;
Lin, Charles ;
Sharp, Phillip A. ;
Giallourakis, Cosmas C. ;
Young, Richard A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (08) :2876-2881
[37]   Splicing-independent recruitment of U1 snRNP to a transcription unit in living cells [J].
Spiluttini, Beatrice ;
Gu, Bo ;
Belagal, Praveen ;
Smirnova, Anna S. ;
Nguyen, Van Trung ;
Hebert, Charles ;
Schmidt, Ute ;
Bertrand, Edouard ;
Darzacq, Xavier ;
Bensaude, Olivier .
JOURNAL OF CELL SCIENCE, 2010, 123 (12) :2084-2092
[38]   RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA [J].
Wagner, Stacey D. ;
Yakovchuk, Petro ;
Gilman, Benjamin ;
Ponicsan, Steven L. ;
Drullinger, Linda F. ;
Kugel, Jennifer F. ;
Goodrich, James A. .
EMBO JOURNAL, 2013, 32 (06) :781-790
[39]   Efficient backsplicing produces translatable circular mRNAs [J].
Wang, Yang ;
Wang, Zefeng .
RNA, 2015, 21 (02) :172-179
[40]   Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes [J].
Werner, Michael S. ;
Ruthenburg, Alexander J. .
CELL REPORTS, 2015, 12 (07) :1089-1098
12345