Growth differentiation factor 15 in different stages of heart failure: potential screening implications

被引：36

作者：

Wang, Fangfang ^{[1
,2
]}

Guo, Yanhong ^{[1
,2
]}

Yu, Haiyi ^{[1
,2
]}

Zheng, Lingbing ^{[1
,2
]}

Mi, Lin ^{[1
,2
]}

Gao, Wei ^{[1
,2
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Hosp 3, Beijing 100871, Peoples R China

[2] Minist Educ, Key Lab Mol, Beijing, Peoples R China

来源：

BIOMARKERS | 2010年 / 15卷 / 08期

关键词：

Growth differentiation factor 15; heart failure; biomarkers; LEFT-VENTRICULAR HYPERTROPHY; SYSTOLIC DYSFUNCTION; NATRIURETIC PEPTIDES; ASSOCIATION; GUIDELINES; MANAGEMENT; DIAGNOSIS; PLASMA; MEMBER;

D O I：

10.3109/1354750X.2010.510580

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Identification of individuals in the early stage of heart failure (HF) may allow earlier initiation of disease-modifying treatment. We evaluated concentrations of the growth differentiation factor (GDF)-15at different stages and its potential screening value in 208 subjects. Plasma GDF-15 was measured by using an enzyme-linked immunosorbent assay. GDF-15 was positively correlated with the stages of HF (r=0.804, p < 0.001). In distinguishing patients with stage B HF, the area under the curve was 0.873 (p < 0.001). These findings indicate that GDF-15 concentration was elevated with the progressing stages of HFand might have potential screening implications for stage B HF.</.

引用

页码：671 / 676

页数：6

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