Four Novel Diterpenoids from Crinipellis sp. 113

Four novel diterpenoids, namely (4/3)-4,4-O-dihydrocrinipellin A (1), (4 beta,8 alpha)-4,4-O,8,8-O-tetrahydrocrinipellin B (2), crinipellin C (3), and crinipellin D (4). along with three known ones, (3 beta,4 beta) 3,3-C,4,4-O-tetrahydrocrinipellin A (5), (4 beta)-4,4-O-dihydrocrinipellin B (6), and phlebiakauranol alcohol, were isolated from the fungal strain Crinpellis sp 113 Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR experiments, and by HR-Q TOF mass spectrometry Antitumor and antibacterial assays with the novel compounds 1-4 were carried out, showing moderate activities against He La cells and no effects on the growth of tested bacteria or yeast