Plasma Soluble P-selectin, Interleukin-6 and S100B Protein in Patients with Schizophrenia: a Pilot Study

被引:5
作者
Pinjari, Omar F. [1 ]
Dasgupta, Swapan K. [2 ,3 ]
Okusaga, Olaoluwa O. [3 ,4 ,5 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston UTHlth, Dept Psychiat & Behav Sci, Houston, TX USA
[2] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
[3] Michael E DeBakey VA Med Ctr, Ctr Translat Res Inflammatory Dis CTRID, Houston, TX 77030 USA
[4] Michael E DeBakey VA Med Ctr, Bipolar & Schizophrenia Treatment BeST Clin, Houston, TX 77030 USA
[5] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
关键词
Schizophrenia; Soluble P-selectin; S100B; IL-6; Astrocytic activation; Microglial activation; Immune activation; Peripheral inflammation; COMMON VARIANTS; IMMUNE CELLS; PSYCHOSIS; BRAIN; INFLAMMATION; NEUROINFLAMMATION; DISEASE; RISK; TSPO;
D O I
10.1007/s11126-021-09954-3
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Microglial activation has long been posited to be involved in the neurobiology of schizophrenia. However, recent studies indicate that schizophrenia is associated with astrocytic activation, rather than microglia activation. Moreover, elevated levels of peripheral inflammatory cytokines associated with schizophrenia could induce or reflect brain inflammation. Therefore, based on: 1) findings of a periphery-to-brain communication pathway involving the cell adhesion molecule, P-selectin, in animal models; 2) dysregulated interleukin-6 (IL-6) and elevated levels of the astrocytic marker, S100B protein, in patients with schizophrenia, we sought to determine correlations between plasma soluble P-selectin (sP-selectin), S100B and IL-6 respectively. We recruited 106 patients with schizophrenia (mean age 33 years, 71.60% male) from the inpatient. sP-selectin, S100B and IL-6 were measured in fasting plasma. We calculated Pearson's and partial correlations between sP-selectin, S100B and IL-6. After controlling for potential confounders, sP-selectin positively correlated with S100B (r=0.31, p=0.004) and IL-6 (r=0.28, P=0.046). The correlation between IL-6 and S 100B (r=0.28, p=0.066) did not reach statistical significance. We propose that in some patients with schizophrenia, immune activation in the periphery is associated with P-selectin-mediated trafficking of inflammation into the brain (most likely via leukocytes), which might be associated with astrocytic activation. Future studies should include healthy controls and first episode/early-onset psychosis patients. Importantly, in vivo imaging of neuroinflammation should be correlated with sP-selectin, IL-6 and S100B in the periphery and the CSF. Finally, the utility of combining sP-selectin, IL-6 and S100B as biomarkers for subtyping patients with schizophrenia, treatment selection and prognosis, should be evaluated in longitudinal studies.
引用
收藏
页码:335 / 345
页数:11
相关论文
共 48 条
[1]   Role of Peripheral Inflammation in Hepatic Encephalopathy [J].
Azhari, Hassan ;
Swain, Mark G. .
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2018, 8 (03) :281-285
[2]   Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study [J].
Bloomfield, Peter S. ;
Selvaraj, Sudhakar ;
Veronese, Mattia ;
Rizzo, Gala ;
Bertoldo, Alessandra ;
Owen, David R. ;
Bloomfield, Michael A. P. ;
Bonoldi, Ilaria ;
Kalk, Nicola ;
Turkheimer, Federico ;
McGuire, Philip ;
de Paola, Vincenzo ;
Howes, Oliver D. .
AMERICAN JOURNAL OF PSYCHIATRY, 2016, 173 (01) :44-52
[3]   Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia [J].
Bourassa, Katelynn A. ;
Postolache, Teodor T. ;
Dagdag, Aline ;
Fuchs, Dietmar ;
Okusaga, Olaoluwa O. .
PTERIDINES, 2020, 31 (01) :61-67
[4]   Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation [J].
Cai, Helen Q. ;
Catts, Vibeke S. ;
Webster, Maree J. ;
Galletly, Cherrie ;
Liu, Dennis ;
O'Donnell, Maryanne ;
Weickert, Thomas W. ;
Weickert, Cynthia Shannon .
MOLECULAR PSYCHIATRY, 2020, 25 (04) :761-775
[5]   Toxoplasma gondii and schizophrenia: a review of published RCTs [J].
Chorlton, Sam D. .
PARASITOLOGY RESEARCH, 2017, 116 (07) :1793-1799
[6]   Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28 [J].
Collste, K. ;
Plaven-Sigray, P. ;
Fatouros-Bergman, H. ;
Victorsson, P. ;
Schain, M. ;
Forsberg, A. ;
Amini, N. ;
Aeinehband, S. ;
Erhardt, S. ;
Halldin, C. ;
Flyckt, L. ;
Farde, L. ;
Cervenka, S. .
MOLECULAR PSYCHIATRY, 2017, 22 (06) :850-856
[7]   Neuroinflammation as measured by positron emission tomography in patients with recent onset and established schizophrenia: implications for immune pathogenesis [J].
Conen, Silke ;
Gregory, Catherine J. ;
Hinz, Rainer ;
Smallman, Richard ;
Corsi-Zuelli, Fabiana ;
Deakin, Bill ;
Talbot, Peter S. .
MOLECULAR PSYCHIATRY, 2021, 26 (09) :5398-5406
[8]   Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia [J].
Corsi-Zuelli, Fabiana ;
Deakin, Bill .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2021, 125 :637-653
[9]   P-Selectin-Mediated Monocyte-Cerebral Endothelium Adhesive Interactions Link Peripheral Organ Inflammation To Sickness Behaviors [J].
D'Mello, Charlotte ;
Riazi, Kiarash ;
Le, Tai ;
Stevens, Katarzyna M. ;
Wang, Arthur ;
McKay, Derek M. ;
Pittman, Quentin J. ;
Swain, Mark G. .
JOURNAL OF NEUROSCIENCE, 2013, 33 (37) :14878-14888
[10]   Elevated Plasma S100B, Psychotic Symptoms, and Cognition in Schizophrenia [J].
Deng, Huiqiong ;
Kahlon, Ramandeep S. ;
Mohite, Satyajit ;
Amin, Pooja A. ;
Zunta-Soares, Giovana ;
Colpo, Gabriela D. ;
Stertz, Laura ;
Fries, Gabriel R. ;
Walss-Bass, Consuelo ;
Soares, Jair C. ;
Okusaga, Olaoluwa O. .
PSYCHIATRIC QUARTERLY, 2018, 89 (01) :53-60