Poly(ethylene glycol)-based polymer carrier of doxorubicin degradable by both enzymatic and chemical hydrolyses

被引：10

作者：

Pechar, M ^{[1
]}

Braunová, A ^{[1
]}

Ulbrich, K ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Macromol Chem, CR-16206 Prague, Czech Republic

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2005年 / 70卷 / 03期

关键词：

drug delivery systems; cancer therapy; doxorubicin; poly(ethylene glycol); peptide synthesis; polymer-supported drugs; antineoplastics; cytostatics; biodegradable polymers;

D O I：

10.1135/cccc20050327

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and characterization of a water-soluble biodegradable multiblock polyurethane based on poly(ethylene glycol) blocks interconnected by a pentapeptide derivative N, N'-bis(aspartylprolyl)lysine is described. The pentapeptide linkages are susceptible both to chemical hydrolysis in neutral and mild acid medium (pH 5) and to enzymatic degradation by lysosomal enzyme cathepsin B. Anti-cancer drug doxorubicin was attached to a hydrazide derivative of the polymer via a hydrolytically labile hydrazone bond. Both the pH-triggered hydrolytic release of the drug and the degradation of the polymer carrier by enzymatic and chemical hydrolysis were studied using liquid chromatography.

引用

页码：327 / 338

页数：12

共 24 条

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