Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report

被引：2
|
作者：
Faria Ornellas, Maria Helena [3 ]
Paixao Maioli, Maria Christina [4 ]
Sampaio Goncalves de Lucena, Stella Beatriz [4 ,5 ]
Bastos, Elenice Ferreira [6 ,7 ]
Chaves, Tatiana Silva [4 ]
de Melo, Karina Vieira [4 ]
Ribeiro-Carvalho, Marilza de Moura [8 ]
Liehr, Thomas [9 ]
Alves, Gilda [1 ,2 ,5 ]
机构：
[1] Univ Estado Rio De Janeiro, Av Prof Manuel de Abreu 444,4 Andar, BR-20550170 Rio De Janeiro, RJ, Brazil
[2] Inst Nacl Canc INCA, Av Prof Manuel de Abreu 444,4 Andar, BR-20550170 Rio De Janeiro, RJ, Brazil
[3] Univ Estado Rio De Janeiro, Pathol Serv, Rio De Janeiro, RJ, Brazil
[4] Univ Estado Rio De Janeiro, Hematol Serv, Rio De Janeiro, RJ, Brazil
[5] Inst Nacl Canc INCA, Res Coordinat, Rio De Janeiro, RJ, Brazil
[6] Univ Estado Rio De Janeiro, Hematol Dept, Rio De Janeiro, RJ, Brazil
[7] Inst Fernandes Figueira Fiocruz, Med Genet Dept, Rio De Janeiro, RJ, Brazil
[8] Univ Estado Rio De Janeiro, Pathol Dept, Rio De Janeiro, RJ, Brazil
[9] Friedrich Schiller Univ, Inst Human Genet, Mol Cytogenet Lab, Jena Univ Hosp, Thuringen, Germany
来源：
SAO PAULO MEDICAL JOURNAL | 2018年 / 136卷 / 04期
关键词：
Leukemia; myeloid; acute; Obesity; Chromosome aberrations; Cytogenetic analysis; HOMOGENEOUSLY STAINING REGION; BODY-MASS INDEX; HEMATOLOGIC MALIGNANCIES; MYELODYSPLASTIC SYNDROMES; MLL GENE; OBESITY; AMPLIFICATION; IMPACT; RISK; CHEMOTHERAPY;
D O I：
10.1590/1516-3180.2016.0252150217
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and FISH (fluorescence in situ hybridization), revealed the presence of complex structural rearrangement involving r(11), add(12)(p13), der(5) and der(13). CONCLUSION: Molecular cytogenetic analysis is suitable for better identification and characterization of chromosomal rearrangements in AML. Case reports like this, as well as population-based studies, are necessary for understanding the karyotypic changes that occur in humans.
引用
收藏
页码：361 / 367
页数：7
相关论文
共 50 条
  • [1] Ring chromosome in myeloid neoplasms is associated with complex karyotype and disease progression
    Rosenbaum, Matthew W.
    Pozdnyakova, Olga
    Geyer, Julia T.
    Dal Cin, Paola
    Hasserjian, Robert P.
    HUMAN PATHOLOGY, 2017, 68 : 40 - 46
  • [2] GINGIVAL ULCERATIONS IN A PATIENT WITH ACUTE MYELOID LEUKEMIA: A CASE REPORT AND LITERATURE REVIEW
    Boras, Vanja Vucicevic
    Juras, Danica Vidovic
    Aurer, Igor
    Basic-Kinda, Sandra
    Mikulic, Mirta
    ACTA CLINICA CROATICA, 2019, 58 (03) : 556 - 560
  • [3] Azacitidine and lenalidomide as an alternative treatment for refractory acute myeloid leukemia: a case report
    Todaro, Juliana
    Bollmann, Patricia Weinschenker
    Rother, Edna Terezinha
    del Giglio, Auro
    SAO PAULO MEDICAL JOURNAL, 2015, 133 (03): : 271 - 274
  • [4] Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case
    Pena, Camila
    Sepulveda, Claudia
    Melo, Joel
    Guerra, Carolina
    REVISTA MEDICA DE CHILE, 2015, 143 (02) : 262 - 265
  • [5] Prognostic Implications of Chromosome 17 Abnormalities in the Context of Monosomal Karyotype in Patients With Acute Myeloid Leukemia and Complex Cytogenetics
    Nazha, Aziz
    Kantarjian, Hagop M.
    Bhatt, Vijaya R.
    Nogueras-Gonzalez, Graciela
    Cortes, Jorge E.
    Kadia, Tapan
    Garcia-Manero, Guillermo
    Abruzzo, Lynne
    Daver, Naval
    Pemmaraju, Naveen
    Quintas-Cardarna, Alfonso
    Ravandi, Farhad
    Keating, Michael
    Borthakur, Gautarn
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2014, 14 (02) : 163 - 171
  • [6] Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia
    Yoshida, Shota
    Onozawa, Masahiro
    Miyashita, Naoki
    Kimura, Hiroyuki
    Takahashi, Shogo
    Yokoyama, Shota
    Matsukawa, Toshihiro
    Hirabayashi, Shinsuke
    Mori, Akio
    Hidaka, Daisuke
    Minauchi, Koichiro
    Shigematsu, Akio
    Hashiguchi, Junichi
    Igarashi, Tetsuyuki
    Kakinoki, Yasutaka
    Tsutsumi, Yutaka
    Ibata, Makoto
    Kobayashi, Hajime
    Haseyama, Yoshihito
    Fujimoto, Katsuya
    Ishihara, Toshimichi
    Sakai, Hajime
    Ota, Shuichi
    Kondo, Takeshi
    Teshima, Takanori
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2023, 117 (04) : 544 - 552
  • [7] Fusariosis in a Patient with Acute Myeloid Leukemia: A Case Report and Review of the Literature
    Mario Delia
    Rosa Monno
    Giorgia Giannelli
    Amato Antonio Stabile Ianora
    Lidia Dalfino
    Domenico Pastore
    Carmen Capolongo
    Carla Calia
    Annamaria Tortorano
    Giorgina Specchia
    Mycopathologia, 2016, 181 : 457 - 463
  • [8] Thrombotic Thrombocytopenic Purpura Triggered by Acute Myeloid Leukemia: A Case Report
    Adimora, Ijele
    Hernandez, Cristhiam M. Rojas
    AMERICAN JOURNAL OF CASE REPORTS, 2022, 23
  • [9] Acute myeloid leukemia after infliximab: a case report
    Lekpa, F. Kemta
    Zahra, K.
    Pautas, C.
    Maury, S.
    Chevalier, X.
    Claudepierre, P.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2009, 27 (06) : 999 - 1000
  • [10] Xeroderma pigmentosum and acute myeloid leukemia: a case report
    Bencharef, H.
    Lamchahab, M.
    Dassouli, D.
    Sraidi, S.
    Guennoun, B.
    Hda, N.
    Oukkache, B.
    Quessar, A.
    JOURNAL OF MEDICAL CASE REPORTS, 2021, 15 (01)
12345