Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma

被引：193

作者：

Xiong, Jie ^{[1
]}

Cui, Bo-Wen ^{[1
]}

Wang, Nan ^{[1
]}

Dai, Yu-Ting ^{[1
,2
]}

Zhang, Hao ^{[3
]}

Wang, Chao-Fu ^{[4
]}

Zhong, Hui-Juan ^{[1
]}

Cheng, Shu ^{[1
]}

Ou-Yang, Bin-Shen ^{[4
]}

Hu, Yu ^{[5
]}

Zhang, Xi ^{[6
]}

Xu, Bin ^{[7
]}

Qian, Wen-Bin ^{[8
]}

Tao, Rong ^{[9
]}

Yan, Feng ^{[10
]}

Hu, Jian-Da ^{[11
]}

Hou, Ming ^{[12
]}

Ma, Xue-Jun ^{[13
]}

Wang, Xin ^{[14
]}

Liu, Yuan-Hua ^{[15
]}

Zhu, Zun-Min ^{[16
]}

Huang, Xiao-Bin ^{[17
]}

Liu, Li ^{[18
]}

Wu, Chong-Yang ^{[19
]}

Huang, Li ^{[20
]}

Shen, Yun-Feng ^{[21
]}

Huang, Rui-Bin ^{[22
]}

Xu, Jing-Yan ^{[23
]}

Wang, Chun ^{[24
]}

Wu, De-Pei ^{[25
]}

Yu, Li ^{[26
]}

Li, Jian-Feng ^{[1
]}

Xu, Peng-Peng ^{[1
]}

Wang, Li ^{[1
,27
]}

Huang, Jin-Yan ^{[1
]}

Chen, Sai-Juan ^{[1
,27
]}

Zhao, Wei-Li ^{[1
,27
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Rui Jin Hosp, State Key Lab Med Genom,Shanghai Inst Hematol,Nat, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Rui Jin Hosp, Dept Otolaryngol, Sch Med, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai Rui Jin Hosp, Dept Pathol, Sch Med, Shanghai, Peoples R China

[5] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Hematol, Wuhan, Peoples R China

[6] Third Mil Med Univ, Xinqiao Hosp, Dept Hematol, Chongqing, Peoples R China

[7] Xiamen Univ, Dept Hematol, Affiliated Hosp 1, Xiamen, Fujian, Peoples R China

[8] Zhejiang Univ, Dept Hematol, Affiliated Hosp 1, Sch Med, Hangzhou, Peoples R China

[9] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Hematol, Sch Med, Shanghai, Peoples R China

[10] Suzhou Univ, Peoples Hosp Changzhou 1, Affiliated Hosp 3, Dept Hematol, Changzhou, Peoples R China

[11] Fujian Med Univ, Fujian Inst Hematol, Union Hosp, Fuzhou, Peoples R China

[12] Shandong Univ, Dept Hematol, Qilu Hosp, Jinan, Peoples R China

[13] Fudan Univ, Shanghai Canc Ctr, Dept Med Oncol, Shanghai, Peoples R China

[14] Shandong Univ, Dept Hematol, Shandong Prov Hosp, Jinan, Peoples R China

[15] Jiangsu Canc Hosp, Dept Med Oncol, Nanjing, Peoples R China

[16] Henan Prov Peoples Hosp, Dept Hematol, Zhengzhou, Peoples R China

[17] Sichuan Prov Peoples Hosp, Dept Hematol, Chengdu, Peoples R China

[18] Fourth Mil Med Univ, Tangdu Hosp, Dept Hematol, Xian, Peoples R China

[19] Lanzhou Univ, Dept Hematol, Hosp 2, Lanzhou, Gansu, Peoples R China

[20] Southwest Med Univ, Dept Oncol & Hematol, Hosp TCM, Luzhou, Peoples R China

[21] Nanjing Med Univ, Dept Hematol, Wuxi Peoples Hosp, Wuxi, Jiangsu, Peoples R China

[22] Nanchang Univ, Dept Hematol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China

[23] Nanjing Drum Tower Hosp, Dept Hematol, Nanjing, Jiangsu, Peoples R China

[24] Shanghai Jiao Tong Univ, Dept Hematol, Shanghai Gen Hosp, Shanghai, Peoples R China

[25] Soochow Univ, Inst Hematol, Affiliated Hosp 1, Suzhou, Peoples R China

[26] Nanchang Univ, Dept Hematol, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China

[27] Lab Mol Pathol, Pole Rech Sino Francais Sci Vivant & Genom, Shanghai, Peoples R China

来源：

CANCER CELL | 2020年 / 37卷 / 03期

基金：

中国国家自然科学基金;

关键词：

EPSTEIN-BARR-VIRUS; FREQUENT MUTATION; EXPRESSION; CANCER; GENES; MYC; PEMBROLIZUMAB; PROGNOSIS; ALIGNMENT; GENETICS;

D O I：

10.1016/j.ccell.2020.02.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes of NKTCL based on genomic structural alterations and EBV sequences, we performed multi-omics study on 128 biopsy samples of newly diagnosed NKTCL and defined three prominent subtypes, which differ significantly in cell of origin, EBV gene expression, transcriptional signatures, and responses to asparaginase-based regimens and targeted therapy. Our findings thus identify molecular networks of EBV-associated pathogenesis and suggest potential clinical strategies on NKTCL.

引用

页码：403 / +

页数：23

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