PSMA-targeted low-molecular double conjugates for diagnostics and therapy

被引：12

作者：

Petrov, Stanislav A. ^{[1
]}

Zyk, Nikolay Y. ^{[1
]}

Machulkin, Aleksei E. ^{[1
]}

Beloglazkina, Elena K. ^{[1
]}

Majouga, Alexander G. ^{[1
,2
,3
]}

机构：

[1] Lomonosov Moscow State Univ, Dept Chem, Leninslde Gory 1-3, Moscow 119991, Russia

[2] Natl Univ Sci & Technol MISiS, Lab Biomed Nanomat, Moscow, Russia

[3] Mendeleev Univ Chem Technol Russia, Moscow, Russia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 225卷

基金：

俄罗斯基础研究基金会;

关键词：

Prostate cancer; Targeted delivery; Double conjugates; PSMA; Anticancer drugs; Cancer diagnosis; GLUTAMATE CARBOXYPEPTIDASE-II; POSITRON-EMISSION-TOMOGRAPHY; UREA-BASED INHIBITORS; MEMBRANE ANTIGEN-EXPRESSION; THIOL-BASED INHIBITORS; ESTRO-SIOG GUIDELINES; PROSTATE-CANCER; PRECLINICAL EVALUATION; BIOLOGICAL EVALUATION; MONOCLONAL-ANTIBODIES;

D O I：

10.1016/j.ejmech.2021.113752

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This review presents data on dual conjugates of therapeutic and diagnostic action for targeted delivery to prostate cancer cells. The works of the last ten years on this topic were analyzed. The mail attention focuses on low-molecular-weight conjugates directed to the prostate-specific membrane antigen (PSMA); the comparison of high and low molecular weight PSMA-targeted conjugates was made. The considered conjugates were divided in the review into two main classes: diagnostic bimodal conjugates (which are containing two fragments for different types of diagnostics), theranostic conjugates (containing both therapeutic and diagnostic agents); also bimodal high molecular weight therapeutic conjugates containing two therapeutic agents are briefly discussed. The data of in vitro and in vivo studies for PSMA-targeted double conjugates available by the beginning of 2021 have been analyzed. (C) 2021 Elsevier Masson SAS. All rights reserved.

引用

页数：30

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