Cancer-targeted photothermal therapy using aptamer-conjugated gold nanoparticles

被引：32
作者：
Hong, Eun Ji [1 ]
Kim, Yoon-Seok [1 ]
Choi, Dae Gun [1 ]
Shim, Min Suk [1 ]
机构：
[1] Incheon Natl Univ, Div Bioengn, Incheon 22012, South Korea
来源：
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2018年 / 67卷
基金：
新加坡国家研究基金会;
关键词：
Aptamer; AS1411; Gold nanoparticle; NIR light; Photothermal therapy; ANTIPROLIFERATIVE ACTIVITY; CELLULAR UPTAKE; AU NANOCAGES; IN-VITRO; CELLS; DELIVERY; AS1411; OLIGODEOXYNUCLEOTIDES; MECHANISM; NANORODS;
D O I：
10.1016/j.jiec.2018.07.017
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Targeted intracellular delivery of therapeutic agents is one of the great challenges for cancer treatment. Aptamers that bind to a variety of biological targets have emerged as new targeting moieties with high specificity for targeted cancer therapy. In this study, near-infrared (NIR) light-absorbing hollow gold nanocages (AuNCs) were synthesized and conjugated with AS1411 aptamer to achieve cancer-targeted photothermal therapy. AuNC functionalized with PEG and AS1411 (AS1411-PEG-AuNC) exhibited selective cellular uptake in breast cancer cells due to selective binding of AS1411 to nucleolin, a protein that is over-expressed in cancer cells over normal cells. As a result, AS1411-PEG-AuNC showed cancer targeted photothermal activity. This study demonstrates that aptamer-conjugated AuNCs are effective tumor-targeting photothermal agents. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：429 / 436
页数：8
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